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| 07.05.2021 | 18:30 | Hannover | - | Darmstadt | 1:2 (0:0) | |
| 18:30 | Holstein Kiel | - | FC St. Pauli | 4:0 (2:0) | ||
| 08.05.2021 | 13:00 | Würzburger Kickers | - | VfL Osnabrück | 1:3 (0:0) | |
| 13:00 | SpVgg Greuther Fürth | - | Karlsruher SC | 2:2 (1:2) | ||
| 13:00 | Fortuna Düsseldorf | - | Eintracht Braunschweig | 2:2 (1:0) | ||
| 09.05.2021 | 13:30 | Erzgebirge Aue | - | SC Paderborn 07 | 3:8 (2:4) | |
| 13:30 | 1. FC Heidenheim 1846 | - | SV Sandhausen | 2:1 (0:1) | ||
| 13:30 | VfL Bochum | - | Jahn Regensburg | 5:1 (2:1) | ||
| 10.05.2021 | 20:30 | Hamburgo | - | 1. FC Nürnberg | 5:2 (3:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VfL Bochum | 32 | 20 | 3 | 9 | 62:37 | 25 | 63 |
| 2 |
|
Holstein Kiel | 32 | 18 | 8 | 6 | 53:29 | 24 | 62 |
| 3 |
|
SpVgg Greuther Fürth | 32 | 16 | 10 | 6 | 62:40 | 22 | 58 |
| 4 |
|
Hamburgo | 32 | 15 | 10 | 7 | 65:41 | 24 | 55 |
| 5 |
|
Fortuna Düsseldorf | 32 | 15 | 8 | 9 | 50:43 | 7 | 53 |
| 6 |
|
1. FC Heidenheim 1846 | 32 | 15 | 6 | 11 | 47:42 | 5 | 51 |
| 7 |
|
FC St. Pauli | 32 | 13 | 8 | 11 | 50:51 | -1 | 47 |
| 8 |
|
SC Paderborn 07 | 32 | 12 | 10 | 10 | 50:40 | 10 | 46 |
| 9 |
|
Karlsruher SC | 32 | 12 | 10 | 10 | 46:41 | 5 | 46 |
| 10 |
|
Darmstadt | 32 | 13 | 6 | 13 | 55:52 | 3 | 45 |
| 11 |
|
Erzgebirge Aue | 32 | 11 | 8 | 13 | 42:49 | -7 | 41 |
| 12 |
|
1. FC Nürnberg | 32 | 10 | 10 | 12 | 43:49 | -6 | 40 |
| 13 |
|
Hannover | 32 | 11 | 6 | 15 | 50:48 | 2 | 39 |
| 14 |
|
Jahn Regensburg | 32 | 8 | 11 | 13 | 34:48 | -14 | 35 |
| 15 |
|
SV Sandhausen | 32 | 9 | 4 | 19 | 38:57 | -19 | 31 |
| 16 |
|
Eintracht Braunschweig | 32 | 7 | 10 | 15 | 29:53 | -24 | 31 |
| 17 |
|
VfL Osnabrück | 32 | 8 | 6 | 18 | 31:54 | -23 | 30 |
| 18 |
|
Würzburger Kickers | 32 | 5 | 6 | 21 | 34:67 | -33 | 21 |
| Ascenso | |
| Permanencia | |
| Permanencia | |
| Descenso |
