I KS Besëlidhja Lezhë - FK Partizani 0:1
V FK Partizani - KS Besëlidhja Lezhë 2:0 (0:0)
I: 03.11.2021 14:00 V: 17.11.2021 13:30 Campeones: FK Partizani
I KS Korabi Peshkopi - KF Teuta Durrës 0:1
V KF Teuta Durrës - KS Korabi Peshkopi 2:0 (1:0)
I: 03.11.2021 14:00 V: 17.11.2021 13:30 Campeones: KF Teuta Durrës
I KF Bylis Ballsh - KF Skënderbeu 1:1
V KF Skënderbeu - KF Bylis Ballsh 4:3 (2:1, 2:2, 2:2) pn.
I: 03.11.2021 14:00 V: 17.11.2021 13:30 Campeones: KF Skënderbeu
I KS Pogradeci - FK Vllaznia 0:2
V FK Vllaznia - KS Pogradeci 6:1 (6:0)
I: 03.11.2021 14:00 V: 17.11.2021 13:30 Campeones: FK Vllaznia
I FK Tomori Berat - KF Laçi 0:1
V KF Laçi - FK Tomori Berat 1:1 (0:1)
I: 03.11.2021 14:00 V: 17.11.2021 13:30 Campeones: KF Laçi
I Flamurtari Vlorë - KS Kastrioti 0:0
V KS Kastrioti - Flamurtari Vlorë 2:4 (1:1)
I: 03.11.2021 14:00 V: 17.11.2021 13:30 Campeones: Flamurtari Vlorë
I Egnatia Rrogozhine - FK Kukësi 3:1
V FK Kukësi - Egnatia Rrogozhine 1:0 (1:0)
I: 03.11.2021 14:00 V: 17.11.2021 13:30 Campeones: Egnatia Rrogozhine
I Dinamo Tiranë - KF Tiranë 2:0
V KF Tiranë - Dinamo Tiranë 7:8 (1:0, 2:0, 2:0) pn.
I: 03.11.2021 16:45 V: 18.11.2021 19:45 Campeones: Dinamo Tiranë