I KS Besëlidhja Lezhë - KF Apolonia Fier 0:1
V KF Apolonia Fier - KS Besëlidhja Lezhë -:-
I: 25.09.2022 15:00 V: 12.10.2022
I Flamurtari Vlorë - FK Vllaznia 2:1
V FK Vllaznia - Flamurtari Vlorë -:-
I: 26.09.2022 15:00 V: 12.10.2022
I KS Pogradeci - KF Bylis Ballsh 0:3
V KF Bylis Ballsh - KS Pogradeci -:-
I: 26.09.2022 15:00 V: 12.10.2022
I KS Besa - KS Korabi Peshkopi 1:1
V KS Korabi Peshkopi - KS Besa -:-
I: 26.09.2022 15:00 V: 12.10.2022
I Labëria FC - FK Kukësi 0:3
V FK Kukësi - Labëria FC -:-
I: 26.09.2022 15:00 V: 12.10.2022
I Luzi United - KF Teuta Durrës 0:0
V KF Teuta Durrës - Luzi United -:-
I: 26.09.2022 15:00 V: 12.10.2022
I Turbina Cërrik - Erzeni Shijak 1:2
V Erzeni Shijak - Turbina Cërrik -:-
I: 26.09.2022 15:00 V: 12.10.2022
I KF Devolli - KF Laçi 0:2
V KF Laçi - KF Devolli -:-
I: 26.09.2022 15:00 V: 12.10.2022
I KS Kastrioti - FK Vora 1:0
V FK Vora - KS Kastrioti -:-
I: 26.09.2022 15:00 V: 12.10.2022
I KF Oriku - FK Partizani -:-
V FK Partizani - KF Oriku -:-
I: 28.09.2022 15:00 V: 12.10.2022
I Butrinti Sarandë - Dinamo Tiranë -:-
V Dinamo Tiranë - Butrinti Sarandë -:-
I: 28.09.2022 15:00 V: 12.10.2022
I KF Lushnja - KF Tërbuni Pukë -:-
V KF Tërbuni Pukë - KF Lushnja -:-
I: 28.09.2022 15:00 V: 12.10.2022
I KS Shkumbini - Egnatia Rrogozhine -:-
V Egnatia Rrogozhine - KS Shkumbini -:-
I: 28.09.2022 15:00 V: 12.10.2022
I KF Maliqi - KF Skënderbeu -:-
V KF Skënderbeu - KF Maliqi -:-
I: 28.09.2022 15:00 V: 12.10.2022
I KS Burreli - FK Tomori Berat -:-
V FK Tomori Berat - KS Burreli -:-
I: 28.09.2022 15:00 V: 12.10.2022
I KF Veleçiku Koplik - KF Tiranë -:-
V KF Tiranë - KF Veleçiku Koplik -:-
I: 28.09.2022 15:00 V: 12.10.2022