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| 15.04.2022 | 02:30 | Gimnasia de La Plata | - | Sarmiento de Junín | 1:3 (0:2) | |
| 21:30 | Tigre | - | Huracán | 2:1 (1:0) | ||
| 16.04.2022 | 00:00 | Central Córdoba SdE | - | Arsenal de Sarandí | 3:3 (1:2) | |
| 00:00 | Aldosivi | - | Rosario Central | 1:0 (1:0) | ||
| 02:30 | Newell's Old Boys | - | Patronato de Paraná | 1:0 (0:0) | ||
| 19:00 | San Lorenzo | - | Platense | 2:2 (2:0) | ||
| 21:30 | Colón de Santa Fe | - | Independiente | 2:2 (1:1) | ||
| 17.04.2022 | 00:00 | Barracas Central | - | Estudiantes | 1:6 (1:4) | |
| 02:30 | Racing Club | - | Unión de Santa Fe | 1:0 (1:0) | ||
| 19:00 | Defensa y Justicia | - | Atlético Tucumán | 1:1 (0:1) | ||
| 19:00 | Godoy Cruz | - | Vélez Sarsfield | 0:0 (0:0) | ||
| 21:30 | Argentinos Juniors | - | Talleres de Córdoba | 2:1 (1:1) | ||
| 18.04.2022 | 00:00 | Boca Juniors | - | CA Lanús | 1:1 (1:1) | |
| 02:30 | Banfield | - | River Plate | 1:2 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing Club | 10 | 7 | 3 | 0 | 20:6 | 14 | 24 |
| 2 |
|
River Plate | 10 | 7 | 1 | 2 | 21:9 | 12 | 22 |
| 3 |
|
Newell's Old Boys | 10 | 6 | 1 | 3 | 14:10 | 4 | 19 |
| 4 |
|
Defensa y Justicia | 10 | 5 | 3 | 2 | 21:15 | 6 | 18 |
| 5 |
|
Argentinos Juniors | 10 | 5 | 2 | 3 | 14:12 | 2 | 17 |
| 6 |
|
Unión de Santa Fe | 10 | 5 | 2 | 3 | 8:6 | 2 | 17 |
| 7 |
|
Sarmiento de Junín | 10 | 5 | 2 | 3 | 15:15 | 0 | 17 |
| 8 |
|
Banfield | 10 | 4 | 2 | 4 | 13:11 | 2 | 14 |
| 9 |
|
Gimnasia de La Plata | 10 | 3 | 3 | 4 | 11:19 | -8 | 12 |
| 10 |
|
San Lorenzo | 10 | 1 | 5 | 4 | 9:12 | -3 | 8 |
| 11 |
|
Platense | 10 | 2 | 2 | 6 | 9:16 | -7 | 8 |
| 12 |
|
Patronato de Paraná | 10 | 2 | 1 | 7 | 6:14 | -8 | 7 |
| 13 |
|
Atlético Tucumán | 10 | 1 | 3 | 6 | 6:17 | -11 | 6 |
| 14 |
|
Talleres de Córdoba | 10 | 1 | 2 | 7 | 6:15 | -9 | 5 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes | 10 | 6 | 3 | 1 | 26:13 | 13 | 21 |
| 2 |
|
Tigre | 10 | 5 | 4 | 1 | 14:5 | 9 | 19 |
| 3 |
|
Aldosivi | 10 | 6 | 1 | 3 | 14:9 | 5 | 19 |
| 4 |
|
Boca Juniors | 10 | 4 | 5 | 1 | 12:9 | 3 | 17 |
| 5 |
|
Colón de Santa Fe | 10 | 3 | 5 | 2 | 14:12 | 2 | 14 |
| 6 |
|
Independiente | 10 | 2 | 6 | 2 | 13:13 | 0 | 12 |
| 7 |
|
Barracas Central | 10 | 4 | 0 | 6 | 12:20 | -8 | 12 |
| 8 |
|
Vélez Sarsfield | 10 | 2 | 5 | 3 | 6:6 | 0 | 11 |
| 9 |
|
Godoy Cruz | 10 | 2 | 5 | 3 | 17:19 | -2 | 11 |
| 10 |
|
Huracán | 10 | 3 | 2 | 5 | 12:14 | -2 | 11 |
| 11 |
|
Central Córdoba SdE | 10 | 2 | 5 | 3 | 11:16 | -5 | 11 |
| 12 |
|
Arsenal de Sarandí | 10 | 1 | 7 | 2 | 16:17 | -1 | 10 |
| 13 |
|
Rosario Central | 10 | 2 | 2 | 6 | 8:14 | -6 | 8 |
| 14 |
|
CA Lanús | 10 | 1 | 4 | 5 | 9:13 | -4 | 7 |
| Playoff | |
| Playoff |
