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| 24.07.2021 | 01:00 | Tristan Suárez | - | Almagro | 1:1 (0:0) | |
| 20:00 | Gimnasia de Jujuy | - | Ramón Santamarina | 1:0 (1:0) | ||
| 20:00 | Guillermo Brown | - | Brown de Adrogué | 0:3 (0:1) | ||
| 20:10 | Ferro Carril Oeste | - | Güemes de SdE | 1:1 (1:0) | ||
| 20:30 | Atlético Rafaela | - | San Martín de San Juan | 0:2 (0:0) | ||
| 20:30 | Barracas Central | - | San Telmo | 3:2 (2:2) | ||
| 20:30 | Independiente Rivadavia | - | Villa Dálmine | 1:1 (1:1) | ||
| 25.07.2021 | 20:05 | Deportivo Morón | - | All Boys | 3:0 (1:0) | |
| 20:30 | Instituto de Córdoba | - | Defensores de Belgrano | 0:2 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Güemes de SdE | 18 | 9 | 7 | 2 | 23:14 | 9 | 34 |
| 2 |
|
Barracas Central | 18 | 8 | 7 | 3 | 23:19 | 4 | 31 |
| 3 |
|
Defensores de Belgrano | 18 | 6 | 9 | 3 | 20:16 | 4 | 27 |
| 4 |
|
Brown de Adrogué | 18 | 7 | 6 | 5 | 19:15 | 4 | 27 |
| 5 |
|
Gimnasia de Jujuy | 18 | 7 | 6 | 5 | 17:14 | 3 | 27 |
| 6 |
|
Deportivo Morón | 18 | 8 | 3 | 7 | 21:20 | 1 | 27 |
| 7 |
|
Almagro | 18 | 8 | 3 | 7 | 22:23 | -1 | 27 |
| 8 |
|
Independiente Rivadavia | 18 | 5 | 10 | 3 | 23:20 | 3 | 25 |
| 9 |
|
Atlético Rafaela | 18 | 6 | 6 | 6 | 20:17 | 3 | 24 |
| 10 |
|
Ferro Carril Oeste | 18 | 6 | 6 | 6 | 17:19 | -2 | 24 |
| 11 |
|
Tristan Suárez | 18 | 6 | 5 | 7 | 28:25 | 3 | 23 |
| 12 |
|
Instituto de Córdoba | 18 | 4 | 10 | 4 | 17:19 | -2 | 22 |
| 13 |
|
All Boys | 18 | 5 | 6 | 7 | 16:18 | -2 | 21 |
| 14 |
|
San Telmo | 18 | 4 | 8 | 6 | 17:24 | -7 | 20 |
| 15 |
|
San Martín de San Juan | 18 | 4 | 7 | 7 | 24:25 | -1 | 19 |
| 16 |
|
Ramón Santamarina | 18 | 4 | 7 | 7 | 16:19 | -3 | 19 |
| 17 |
|
Guillermo Brown | 18 | 2 | 8 | 8 | 12:21 | -9 | 14 |
| 18 |
|
Villa Dálmine | 18 | 1 | 10 | 7 | 7:14 | -7 | 13 |
| Próxima ronda | |
| Playoff |
