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| 16.04.2022 | 20:30 | Temperley | - | Chaco For Ever | 0:0 (0:0) | |
| 20:30 | Deportivo Madryn | - | Atlanta | 4:1 (2:0) | ||
| 20:30 | Deportivo Morón | - | San Martín de San Juan | 0:0 (0:0) | ||
| 20:30 | Flandria | - | San Telmo | 3:3 (1:2) | ||
| 20:30 | Villa Dálmine | - | Güemes de SdE | 0:0 (0:0) | ||
| 21:05 | Ferro Carril Oeste | - | San Martín de Tucumán | 1:4 (1:3) | ||
| 17.04.2022 | 00:30 | Alvarado | - | Ramón Santamarina | 3:0 (1:0) | |
| 01:35 | Belgrano | - | Deportivo Riestra | 2:1 (0:0) | ||
| 19:35 | Deportivo Maipú | - | Chacarita Juniors | 1:1 (1:0) | ||
| 20:00 | Gimnasia de Jujuy | - | Gimnasia de Mendoza | 0:3 (0:1) | ||
| 20:30 | Almagro | - | Atlético Rafaela | 3:1 (3:1) | ||
| 21:35 | Almirante Brown | - | All Boys | 2:2 (1:1) | ||
| 18.04.2022 | 01:00 | Mitre de SdE | - | Tristan Suárez | 2:1 (1:1) | |
| 01:00 | Estudiantes de Río Cuarto | - | Estudiantes de Caseros | 2:1 (2:0) | ||
| 20:30 | Sacachispas | - | Agropecuario Argentino | 0:0 (0:0) | ||
| 19.04.2022 | 00:10 | Nueva Chicago | - | Guillermo Brown | 2:2 (0:1) | |
| 01:35 | Quilmes | - | Brown de Adrogué | 1:1 (0:0) | ||
| 02:10 | Independiente Rivadavia | - | Defensores de Belgrano | 3:1 (2:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano | 11 | 9 | 1 | 1 | 17:8 | 9 | 28 |
| 2 |
|
San Martín de Tucumán | 11 | 7 | 3 | 1 | 18:8 | 10 | 24 |
| 3 |
|
Brown de Adrogué | 11 | 5 | 5 | 1 | 17:9 | 8 | 20 |
| 4 |
|
Instituto de Córdoba | 10 | 5 | 5 | 0 | 12:7 | 5 | 20 |
| 5 |
|
Chacarita Juniors | 11 | 5 | 3 | 3 | 19:14 | 5 | 18 |
| 6 |
|
Deportivo Madryn | 11 | 4 | 5 | 2 | 14:9 | 5 | 17 |
| 7 |
|
Deportivo Riestra | 10 | 4 | 5 | 1 | 8:4 | 4 | 17 |
| 8 |
|
Almirante Brown | 11 | 4 | 5 | 2 | 14:12 | 2 | 17 |
| 9 |
|
Deportivo Maipú | 11 | 4 | 5 | 2 | 12:10 | 2 | 17 |
| 10 |
|
Guillermo Brown | 11 | 5 | 2 | 4 | 11:10 | 1 | 17 |
| 11 |
|
Estudiantes de Río Cuarto | 11 | 4 | 5 | 2 | 10:9 | 1 | 17 |
| 12 |
|
Almagro | 11 | 5 | 1 | 5 | 11:14 | -3 | 16 |
| 13 |
|
Gimnasia de Mendoza | 10 | 4 | 3 | 3 | 14:6 | 8 | 15 |
| 14 |
|
All Boys | 10 | 3 | 6 | 1 | 14:11 | 3 | 15 |
| 15 |
|
Chaco For Ever | 11 | 2 | 9 | 0 | 11:8 | 3 | 15 |
| 16 |
|
Defensores de Belgrano | 11 | 4 | 3 | 4 | 12:14 | -2 | 15 |
| 17 |
|
San Martín de San Juan | 11 | 4 | 2 | 5 | 13:11 | 2 | 14 |
| 18 |
|
Agropecuario Argentino | 11 | 3 | 5 | 3 | 11:9 | 2 | 14 |
| 19 |
|
Atlanta | 11 | 3 | 5 | 3 | 13:12 | 1 | 14 |
| 20 |
|
Estudiantes de Caseros | 11 | 3 | 5 | 3 | 9:9 | 0 | 14 |
| 21 |
|
Independiente Rivadavia | 10 | 4 | 2 | 4 | 11:12 | -1 | 14 |
| 22 |
|
Alvarado | 11 | 3 | 4 | 4 | 13:18 | -5 | 13 |
| 23 |
|
Atlético Rafaela | 11 | 3 | 3 | 5 | 12:11 | 1 | 12 |
|
Quilmes | 10 | 2 | 6 | 2 | 12:11 | 1 | 12 | |
| 25 |
|
Deportivo Morón | 11 | 2 | 6 | 3 | 6:6 | 0 | 12 |
| 26 |
|
Nueva Chicago | 11 | 2 | 6 | 3 | 11:13 | -2 | 12 |
| 27 |
|
Gimnasia de Jujuy | 11 | 2 | 5 | 4 | 9:16 | -7 | 11 |
| 28 |
|
Sacachispas | 10 | 1 | 7 | 2 | 9:9 | 0 | 10 |
| 29 |
|
Flandria | 11 | 2 | 4 | 5 | 16:19 | -3 | 10 |
| 30 |
|
Temperley | 11 | 2 | 3 | 6 | 9:14 | -5 | 9 |
| 31 |
|
Villa Dálmine | 11 | 1 | 6 | 4 | 11:19 | -8 | 9 |
| 32 |
|
San Telmo | 10 | 1 | 6 | 3 | 8:16 | -8 | 9 |
| 33 |
|
Ferro Carril Oeste | 10 | 1 | 5 | 4 | 9:14 | -5 | 8 |
| 34 |
|
Tristan Suárez | 11 | 0 | 7 | 4 | 13:17 | -4 | 7 |
| 35 |
|
Mitre de SdE | 10 | 1 | 4 | 5 | 7:13 | -6 | 7 |
| 36 |
|
Ramón Santamarina | 11 | 1 | 4 | 6 | 10:17 | -7 | 7 |
| 37 |
|
Güemes de SdE | 10 | 0 | 5 | 5 | 4:11 | -7 | 5 |
| Ascenso | |
| Playoff | |
| Playoff | |
| Descenso |
