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| 22.07.2022 | 19:00 | Estudiantes de Río Cuarto | - | Temperley | 0:0 (0:0) | |
| 20:00 | Deportivo Maipú | - | Villa Dálmine | 4:0 (3:0) | ||
| 20:00 | Sacachispas | - | Gimnasia de Mendoza | 0:0 (0:0) | ||
| 21:00 | Mitre de SdE | - | All Boys | 1:0 (0:0) | ||
| 23.07.2022 | 00:00 | Alvarado | - | Flandria | 2:2 (0:1) | |
| 00:00 | Tristan Suárez | - | San Martín de San Juan | 3:0 (1:0) | ||
| 00:10 | Ferro Carril Oeste | - | Güemes de SdE | 1:0 (0:0) | ||
| 02:10 | San Martín de Tucumán | - | Atlanta | 0:0 (0:0) | ||
| 20:00 | Almagro | - | Gimnasia de Jujuy | 2:0 (2:0) | ||
| 20:00 | Brown de Adrogué | - | Ramón Santamarina | 0:1 (0:1) | ||
| 20:30 | Chacarita Juniors | - | Atlético Rafaela | 3:1 (1:0) | ||
| 20:30 | Defensores de Belgrano | - | Estudiantes de Caseros | 1:0 (1:0) | ||
| 20:30 | Independiente Rivadavia | - | Deportivo Riestra | 2:0 (1:0) | ||
| 20:35 | Nueva Chicago | - | Almirante Brown | 2:2 (0:2) | ||
| 21:00 | Agropecuario Argentino | - | Chaco For Ever | 0:0 (0:0) | ||
| 22:40 | Instituto de Córdoba | - | San Telmo | 2:0 (1:0) | ||
| 10.08.2022 | 20:00 | Deportivo Madryn | - | Deportivo Morón | 0:1 (0:0) | |
| 25.08.2022 | 02:10 | Quilmes | - | Belgrano | 0:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano | 24 | 17 | 5 | 2 | 29:12 | 17 | 56 |
| 2 |
|
Instituto de Córdoba | 24 | 13 | 8 | 3 | 31:16 | 15 | 47 |
| 3 |
|
San Martín de Tucumán | 24 | 12 | 10 | 2 | 30:15 | 15 | 46 |
| 4 |
|
All Boys | 24 | 10 | 12 | 2 | 35:19 | 16 | 42 |
| 5 |
|
Gimnasia de Mendoza | 24 | 10 | 10 | 4 | 28:12 | 16 | 40 |
| 6 |
|
Estudiantes de Río Cuarto | 25 | 10 | 10 | 5 | 28:23 | 5 | 40 |
| 7 |
|
Almagro | 25 | 11 | 6 | 8 | 23:22 | 1 | 39 |
| 8 |
|
San Martín de San Juan | 25 | 11 | 5 | 9 | 35:26 | 9 | 38 |
| 9 |
|
Brown de Adrogué | 24 | 10 | 8 | 6 | 29:22 | 7 | 38 |
| 10 |
|
Independiente Rivadavia | 24 | 10 | 7 | 7 | 32:23 | 9 | 37 |
| 11 |
|
Deportivo Madryn | 25 | 8 | 11 | 6 | 33:26 | 7 | 35 |
| 12 |
|
Chacarita Juniors | 24 | 9 | 8 | 7 | 36:30 | 6 | 35 |
| 13 |
|
Defensores de Belgrano | 24 | 8 | 11 | 5 | 26:21 | 5 | 35 |
| 14 |
|
Deportivo Maipú | 25 | 7 | 13 | 5 | 28:22 | 6 | 34 |
| 15 |
|
Chaco For Ever | 25 | 7 | 13 | 5 | 26:20 | 6 | 34 |
| 16 |
|
Deportivo Riestra | 24 | 7 | 12 | 5 | 22:20 | 2 | 33 |
| 17 |
|
Estudiantes de Caseros | 25 | 8 | 8 | 9 | 20:22 | -2 | 32 |
| 18 |
|
Guillermo Brown | 24 | 9 | 5 | 10 | 20:23 | -3 | 32 |
| 19 |
|
Agropecuario Argentino | 24 | 6 | 12 | 6 | 22:22 | 0 | 30 |
| 20 |
|
Ferro Carril Oeste | 24 | 7 | 9 | 8 | 20:25 | -5 | 30 |
| 21 |
|
Güemes de SdE | 24 | 7 | 8 | 9 | 19:19 | 0 | 29 |
| 22 |
|
Gimnasia de Jujuy | 24 | 7 | 8 | 9 | 25:31 | -6 | 29 |
| 23 |
|
Deportivo Morón | 24 | 5 | 13 | 6 | 15:14 | 1 | 28 |
| 24 |
|
Quilmes | 24 | 6 | 10 | 8 | 28:30 | -2 | 28 |
| 25 |
|
Mitre de SdE | 24 | 7 | 7 | 10 | 24:27 | -3 | 28 |
| 26 |
|
Almirante Brown | 24 | 5 | 12 | 7 | 26:30 | -4 | 27 |
| 27 |
|
Atlanta | 25 | 5 | 11 | 9 | 19:23 | -4 | 26 |
| 28 |
|
Alvarado | 25 | 6 | 8 | 11 | 25:40 | -15 | 26 |
| 29 |
|
Temperley | 24 | 5 | 10 | 9 | 20:28 | -8 | 25 |
| 30 |
|
Nueva Chicago | 25 | 5 | 10 | 10 | 26:35 | -9 | 25 |
| 31 |
|
Tristan Suárez | 24 | 5 | 8 | 11 | 27:30 | -3 | 23 |
| 32 |
|
Atlético Rafaela | 25 | 4 | 11 | 10 | 23:30 | -7 | 23 |
| 33 |
|
Sacachispas | 24 | 3 | 14 | 7 | 17:25 | -8 | 23 |
| 34 |
|
San Telmo | 24 | 5 | 8 | 11 | 23:39 | -16 | 23 |
| 35 |
|
Flandria | 24 | 4 | 9 | 11 | 25:33 | -8 | 21 |
| 36 |
|
Villa Dálmine | 24 | 3 | 11 | 10 | 27:43 | -16 | 20 |
| 37 |
|
Ramón Santamarina | 25 | 3 | 9 | 13 | 16:40 | -24 | 18 |
| Ascenso | |
| Playoff | |
| Playoff | |
| Descenso |
