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| 05.11.2021 | 23:00 | Defensa y Justicia | - | Rosario Central | 3:0 (2:0) | |
| 06.11.2021 | 01:15 | CA Lanús | - | Estudiantes | 1:1 (1:1) | |
| 19:45 | Godoy Cruz | - | Talleres de Córdoba | 0:2 (0:0) | ||
| 19:45 | Colón de Santa Fe | - | Platense | 3:0 (1:0) | ||
| 22:00 | Independiente | - | Arsenal de Sarandí | 3:0 (2:0) | ||
| 07.11.2021 | 00:15 | Atlético Tucumán | - | Racing Club | 0:2 (0:0) | |
| 19:45 | Sarmiento de Junín | - | Central Córdoba SdE | 1:3 (0:1) | ||
| 19:45 | Gimnasia de La Plata | - | Banfield | 0:1 (0:0) | ||
| 22:00 | Vélez Sarsfield | - | San Lorenzo | 2:1 (2:1) | ||
| 08.11.2021 | 00:15 | River Plate | - | Patronato de Paraná | 5:0 (4:0) | |
| 20:45 | Newell's Old Boys | - | Unión de Santa Fe | 1:0 (0:0) | ||
| 23:00 | Huracán | - | Argentinos Juniors | 1:1 (0:1) | ||
| 09.11.2021 | 01:15 | Aldosivi | - | Boca Juniors | 0:3 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
River Plate | 20 | 14 | 4 | 2 | 43:13 | 30 | 46 |
| 2 |
|
Talleres de Córdoba | 20 | 12 | 3 | 5 | 30:19 | 11 | 39 |
| 3 |
|
CA Lanús | 20 | 10 | 5 | 5 | 35:30 | 5 | 35 |
| 4 |
|
Vélez Sarsfield | 20 | 9 | 7 | 4 | 29:16 | 13 | 34 |
| 5 |
|
Defensa y Justicia | 20 | 9 | 7 | 4 | 30:18 | 12 | 34 |
| 6 |
|
Boca Juniors | 20 | 9 | 6 | 5 | 24:16 | 8 | 33 |
| 7 |
|
Colón de Santa Fe | 20 | 9 | 5 | 6 | 19:22 | -3 | 32 |
| 8 |
|
Independiente | 20 | 8 | 7 | 5 | 22:17 | 5 | 31 |
| 9 |
|
Estudiantes | 20 | 7 | 8 | 5 | 29:22 | 7 | 29 |
| 10 |
|
Huracán | 20 | 7 | 8 | 5 | 19:16 | 3 | 29 |
| 11 |
|
Gimnasia de La Plata | 20 | 7 | 7 | 6 | 17:19 | -2 | 28 |
| 12 |
|
Racing Club | 20 | 6 | 8 | 6 | 18:14 | 4 | 26 |
| 13 |
|
Godoy Cruz | 20 | 7 | 5 | 8 | 28:26 | 2 | 26 |
| 14 |
|
Argentinos Juniors | 20 | 6 | 7 | 7 | 19:20 | -1 | 25 |
| 15 |
|
Unión de Santa Fe | 20 | 7 | 4 | 9 | 23:27 | -4 | 25 |
| 16 |
|
Rosario Central | 20 | 7 | 3 | 10 | 27:31 | -4 | 24 |
| 17 |
|
Platense | 20 | 5 | 8 | 7 | 24:26 | -2 | 23 |
| 18 |
|
Sarmiento de Junín | 20 | 6 | 5 | 9 | 22:26 | -4 | 23 |
| 19 |
|
Newell's Old Boys | 20 | 6 | 5 | 9 | 20:26 | -6 | 23 |
| 20 |
|
Banfield | 20 | 4 | 9 | 7 | 16:22 | -6 | 21 |
| 21 |
|
Atlético Tucumán | 20 | 5 | 6 | 9 | 20:32 | -12 | 21 |
| 22 |
|
Aldosivi | 20 | 6 | 3 | 11 | 19:33 | -14 | 21 |
| 23 |
|
Patronato de Paraná | 20 | 4 | 8 | 8 | 20:29 | -9 | 20 |
| 24 |
|
San Lorenzo | 20 | 5 | 5 | 10 | 18:27 | -9 | 20 |
| 25 |
|
Central Córdoba SdE | 20 | 3 | 8 | 9 | 21:27 | -6 | 17 |
| 26 |
|
Arsenal de Sarandí | 20 | 3 | 7 | 10 | 8:26 | -18 | 16 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
