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| 07.08.2021 | 00:00 | Sarmiento de Junín | - | Rosario Central | 1:0 (0:0) | |
| 02:15 | Newell's Old Boys | - | Platense | 1:0 (0:0) | ||
| 18:30 | Banfield | - | Talleres de Córdoba | 0:1 (0:0) | ||
| 20:45 | Unión de Santa Fe | - | San Lorenzo | 4:0 (3:0) | ||
| 23:00 | Huracán | - | CA Lanús | 0:1 (0:0) | ||
| 08.08.2021 | 01:15 | Godoy Cruz | - | River Plate | 2:1 (1:0) | |
| 18:30 | Gimnasia de La Plata | - | Atlético Tucumán | 1:0 (0:0) | ||
| 20:45 | Vélez Sarsfield | - | Colón de Santa Fe | 0:1 (0:0) | ||
| 23:00 | Boca Juniors | - | Argentinos Juniors | 1:1 (0:1) | ||
| 09.08.2021 | 01:15 | Independiente | - | Racing Club | 1:0 (0:0) | |
| 23:00 | Arsenal de Sarandí | - | Patronato de Paraná | 2:2 (2:1) | ||
| 23:00 | Aldosivi | - | Defensa y Justicia | 1:0 (0:0) | ||
| 10.08.2021 | 01:15 | Central Córdoba SdE | - | Estudiantes | 1:2 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Independiente | 5 | 3 | 2 | 0 | 5:1 | 4 | 11 |
| 2 |
|
CA Lanús | 5 | 3 | 1 | 1 | 10:7 | 3 | 10 |
| 3 |
|
Newell's Old Boys | 5 | 3 | 1 | 1 | 8:5 | 3 | 10 |
| 4 |
|
Colón de Santa Fe | 5 | 3 | 1 | 1 | 6:6 | 0 | 10 |
| 5 |
|
Estudiantes | 5 | 3 | 0 | 2 | 11:6 | 5 | 9 |
| 6 |
|
Godoy Cruz | 5 | 3 | 0 | 2 | 7:6 | 1 | 9 |
| 7 |
|
Aldosivi | 5 | 3 | 0 | 2 | 4:5 | -1 | 9 |
| 8 |
|
Patronato de Paraná | 5 | 2 | 2 | 1 | 6:4 | 2 | 8 |
| 9 |
|
Racing Club | 5 | 2 | 2 | 1 | 3:1 | 2 | 8 |
| 10 |
|
Gimnasia de La Plata | 5 | 2 | 2 | 1 | 6:5 | 1 | 8 |
| 11 |
|
San Lorenzo | 5 | 2 | 2 | 1 | 5:6 | -1 | 8 |
| 12 |
|
River Plate | 5 | 2 | 1 | 2 | 10:5 | 5 | 7 |
| 13 |
|
Talleres de Córdoba | 5 | 2 | 1 | 2 | 6:5 | 1 | 7 |
| 14 |
|
Atlético Tucumán | 5 | 2 | 1 | 2 | 5:6 | -1 | 7 |
| 15 |
|
Argentinos Juniors | 5 | 1 | 3 | 1 | 3:3 | 0 | 6 |
|
Banfield | 5 | 1 | 3 | 1 | 3:3 | 0 | 6 | |
| 17 |
|
Sarmiento de Junín | 5 | 2 | 0 | 3 | 2:6 | -4 | 6 |
| 18 |
|
Unión de Santa Fe | 5 | 1 | 2 | 2 | 6:7 | -1 | 5 |
| 19 |
|
Central Córdoba SdE | 5 | 1 | 2 | 2 | 5:6 | -1 | 5 |
| 20 |
|
Huracán | 5 | 1 | 2 | 2 | 4:5 | -1 | 5 |
| 21 |
|
Arsenal de Sarandí | 5 | 1 | 2 | 2 | 4:9 | -5 | 5 |
| 22 |
|
Defensa y Justicia | 5 | 1 | 1 | 3 | 5:7 | -2 | 4 |
| 23 |
|
Boca Juniors | 5 | 0 | 4 | 1 | 2:4 | -2 | 4 |
| 24 |
|
Vélez Sarsfield | 5 | 0 | 3 | 2 | 0:2 | -2 | 3 |
| 25 |
|
Rosario Central | 5 | 1 | 0 | 4 | 3:6 | -3 | 3 |
| 26 |
|
Platense | 5 | 0 | 2 | 3 | 3:6 | -3 | 2 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
