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| 29.09.2022 | 20:30 | Barracas Central | - | Gimnasia de La Plata | 1:1 (1:0) | |
| 01.10.2022 | 00:00 | Tigre | - | Aldosivi | 3:0 (2:0) | |
| 00:00 | Estudiantes | - | Colón de Santa Fe | 2:4 (1:1) | ||
| 02:30 | Racing Club | - | Rosario Central | 4:3 (1:3) | ||
| 02:30 | Unión de Santa Fe | - | Newell's Old Boys | 0:1 (0:1) | ||
| 18:00 | Central Córdoba SdE | - | Sarmiento de Junín | 0:0 (0:0) | ||
| 18:00 | Platense | - | Defensa y Justicia | 0:0 (0:0) | ||
| 20:30 | San Lorenzo | - | Huracán | 1:0 (1:0) | ||
| 23:00 | Banfield | - | Godoy Cruz | 1:1 (0:1) | ||
| 02.10.2022 | 01:30 | Arsenal de Sarandí | - | Independiente | 0:1 (0:1) | |
| 20:30 | Patronato de Paraná | - | Atlético Tucumán | 2:1 (1:1) | ||
| 23:00 | Boca Juniors | - | Vélez Sarsfield | 1:0 (0:0) | ||
| 23:30 | Talleres de Córdoba | - | CA Lanús | 0:1 (0:0) | ||
| 03.10.2022 | 01:30 | Argentinos Juniors | - | River Plate | 0:3 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors | 22 | 13 | 3 | 6 | 27:22 | 5 | 42 |
| 2 |
|
Atlético Tucumán | 22 | 11 | 8 | 3 | 27:14 | 13 | 41 |
| 3 |
|
Racing Club | 22 | 11 | 7 | 4 | 32:19 | 13 | 40 |
| 4 |
|
Huracán | 22 | 9 | 10 | 3 | 26:16 | 10 | 37 |
| 5 |
|
Gimnasia de La Plata | 22 | 10 | 7 | 5 | 22:13 | 9 | 37 |
| 6 |
|
River Plate | 22 | 10 | 5 | 7 | 32:18 | 14 | 35 |
| 7 |
|
Tigre | 22 | 8 | 9 | 5 | 32:24 | 8 | 33 |
| 8 |
|
Argentinos Juniors | 22 | 10 | 3 | 9 | 26:23 | 3 | 33 |
| 9 |
|
Godoy Cruz | 22 | 9 | 6 | 7 | 24:23 | 1 | 33 |
| 10 |
|
Newell's Old Boys | 22 | 9 | 5 | 8 | 20:19 | 1 | 32 |
| 11 |
|
Patronato de Paraná | 22 | 8 | 7 | 7 | 26:23 | 3 | 31 |
| 12 |
|
Platense | 22 | 7 | 10 | 5 | 19:16 | 3 | 31 |
| 13 |
|
San Lorenzo | 22 | 6 | 12 | 4 | 24:21 | 3 | 30 |
| 14 |
|
Independiente | 22 | 8 | 6 | 8 | 24:23 | 1 | 30 |
| 15 |
|
Sarmiento de Junín | 22 | 8 | 5 | 9 | 22:24 | -2 | 29 |
| 16 |
|
Defensa y Justicia | 22 | 7 | 8 | 7 | 20:22 | -2 | 29 |
| 17 |
|
Central Córdoba SdE | 22 | 8 | 4 | 10 | 27:28 | -1 | 28 |
| 18 |
|
Barracas Central | 22 | 7 | 7 | 8 | 25:30 | -5 | 28 |
| 19 |
|
Unión de Santa Fe | 22 | 7 | 6 | 9 | 24:29 | -5 | 27 |
| 20 |
|
Estudiantes | 22 | 7 | 6 | 9 | 22:27 | -5 | 27 |
| 21 |
|
Talleres de Córdoba | 22 | 6 | 8 | 8 | 19:20 | -1 | 26 |
| 22 |
|
Banfield | 22 | 6 | 8 | 8 | 22:25 | -3 | 26 |
| 23 |
|
Rosario Central | 22 | 6 | 7 | 9 | 19:24 | -5 | 25 |
| 24 |
|
Arsenal de Sarandí | 22 | 4 | 11 | 7 | 21:25 | -4 | 23 |
| 25 |
|
Colón de Santa Fe | 22 | 5 | 7 | 10 | 19:30 | -11 | 22 |
| 26 |
|
CA Lanús | 22 | 5 | 5 | 12 | 20:30 | -10 | 20 |
| 27 |
|
Vélez Sarsfield | 22 | 3 | 10 | 9 | 23:29 | -6 | 19 |
| 28 |
|
Aldosivi | 22 | 3 | 4 | 15 | 12:39 | -27 | 13 |
