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| 26.07.2021 | 20:00 | Vélez Sarsfield II | - | Defensa y Justicia II | 0:0 (0:0) | |
| 27.07.2021 | 15:00 | Aldosivi II | - | Racing Club II | 2:0 (1:0) | |
| 15:00 | Huracán II | - | Colón de Santa Fe II | 0:1 (0:1) | ||
| 15:00 | Sarmiento de Junín II | - | Platense II | 2:0 (2:0) | ||
| 15:00 | Godoy Cruz II | - | Atlético Tucumán II | 2:2 (2:2) | ||
| 15:00 | Central Córdoba SdE II | - | Talleres de Córdoba II | 1:2 (1:1) | ||
| 15:00 | Gimnasia de La Plata II | - | Rosario Central II | 4:3 (1:0) | ||
| 15:00 | Independiente II | - | Patronato de Paraná II | 0:1 (0:1) | ||
| 15:00 | Newell's Old Boys II | - | Estudiantes II | 1:3 (1:3) | ||
| 15:00 | Unión de Santa Fe II | - | Banfield II | 0:1 (0:1) | ||
| 18:45 | Lanús II | - | River Plate II | 0:1 (0:1) | ||
| 20:00 | Arsenal de Sarandí II | - | Argentinos Juniors II | 3:1 (0:0) | ||
| 11.11.2021 | 14:00 | Boca Juniors II | - | San Lorenzo II | 4:1 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes II | 3 | 2 | 1 | 0 | 7:4 | 3 | 7 |
| 2 |
|
Gimnasia de La Plata II | 3 | 2 | 1 | 0 | 5:3 | 2 | 7 |
| 3 |
|
Boca Juniors II | 3 | 2 | 0 | 1 | 7:3 | 4 | 6 |
| 4 |
|
River Plate II | 3 | 2 | 0 | 1 | 4:2 | 2 | 6 |
| 5 |
|
Aldosivi II | 3 | 2 | 0 | 1 | 4:3 | 1 | 6 |
| 6 |
|
Colón de Santa Fe II | 3 | 2 | 0 | 1 | 3:2 | 1 | 6 |
| 7 |
|
Banfield II | 3 | 2 | 0 | 1 | 4:4 | 0 | 6 |
| 8 |
|
San Lorenzo II | 3 | 2 | 0 | 1 | 3:4 | -1 | 6 |
| 9 |
|
Rosario Central II | 3 | 1 | 1 | 1 | 7:5 | 2 | 4 |
| 10 |
|
Independiente II | 3 | 1 | 1 | 1 | 5:3 | 2 | 4 |
| 11 |
|
Huracán II | 3 | 1 | 1 | 1 | 3:1 | 2 | 4 |
| 12 |
|
Arsenal de Sarandí II | 3 | 1 | 1 | 1 | 4:3 | 1 | 4 |
|
Sarmiento de Junín II | 3 | 1 | 1 | 1 | 4:3 | 1 | 4 | |
| 14 |
|
Talleres de Córdoba II | 3 | 1 | 1 | 1 | 4:4 | 0 | 4 |
| 15 |
|
Patronato de Paraná II | 3 | 1 | 1 | 1 | 3:3 | 0 | 4 |
| 16 |
|
Lanús II | 3 | 1 | 1 | 1 | 1:1 | 0 | 4 |
| 17 |
|
Defensa y Justicia II | 3 | 1 | 1 | 1 | 2:4 | -2 | 4 |
| 18 |
|
Atlético Tucumán II | 3 | 0 | 3 | 0 | 2:2 | 0 | 3 |
| 19 |
|
Platense II | 3 | 1 | 0 | 2 | 2:3 | -1 | 3 |
| 20 |
|
Unión de Santa Fe II | 3 | 1 | 0 | 2 | 1:3 | -2 | 3 |
| 21 |
|
Argentinos Juniors II | 3 | 1 | 0 | 2 | 4:7 | -3 | 3 |
|
Newell's Old Boys II | 3 | 1 | 0 | 2 | 4:7 | -3 | 3 | |
| 23 |
|
Godoy Cruz II | 3 | 0 | 2 | 1 | 4:5 | -1 | 2 |
| 24 |
|
Racing Club II | 3 | 0 | 2 | 1 | 1:3 | -2 | 2 |
| 25 |
|
Vélez Sarsfield II | 3 | 0 | 2 | 1 | 1:4 | -3 | 2 |
| 26 |
|
Central Córdoba SdE II | 3 | 0 | 0 | 3 | 2:5 | -3 | 0 |
