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| 13.08.2021 | 15:00 | Argentinos Juniors II | - | Banfield II | 0:0 (0:0) | |
| 15:00 | Huracán II | - | Unión de Santa Fe II | 0:1 (0:1) | ||
| 15:00 | Lanús II | - | Godoy Cruz II | 5:1 (3:0) | ||
| 15:00 | Patronato de Paraná II | - | Central Córdoba SdE II | 3:1 (0:0) | ||
| 15:00 | Colón de Santa Fe II | - | Gimnasia de La Plata II | 2:1 (1:0) | ||
| 15:00 | Defensa y Justicia II | - | Sarmiento de Junín II | 3:0 (2:0) | ||
| 15:00 | Estudiantes II | - | Boca Juniors II | 2:1 (1:0) | ||
| 15:00 | Platense II | - | Arsenal de Sarandí II | 1:0 (1:0) | ||
| 15:00 | Rosario Central II | - | Independiente II | 3:1 (2:0) | ||
| 15:00 | Talleres de Córdoba II | - | San Lorenzo II | 1:0 (0:0) | ||
| 20:00 | River Plate II | - | Vélez Sarsfield II | 1:2 (0:2) | ||
| 14.08.2021 | 23:30 | Atlético Tucumán II | - | Aldosivi II | 3:2 (1:1) | |
| 16.08.2021 | 20:00 | Racing Club II | - | Newell's Old Boys II | 1:1 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes II | 6 | 4 | 2 | 0 | 12:7 | 5 | 14 |
| 2 |
|
Gimnasia de La Plata II | 6 | 4 | 1 | 1 | 12:5 | 7 | 13 |
| 3 |
|
Lanús II | 6 | 4 | 1 | 1 | 10:3 | 7 | 13 |
| 4 |
|
Banfield II | 6 | 4 | 1 | 1 | 10:6 | 4 | 13 |
| 5 |
|
Colón de Santa Fe II | 6 | 4 | 1 | 1 | 7:3 | 4 | 13 |
| 6 |
|
River Plate II | 6 | 4 | 0 | 2 | 8:4 | 4 | 12 |
| 7 |
|
Platense II | 6 | 4 | 0 | 2 | 6:4 | 2 | 12 |
| 8 |
|
Rosario Central II | 6 | 3 | 2 | 1 | 16:9 | 7 | 11 |
| 9 |
|
Patronato de Paraná II | 6 | 3 | 1 | 2 | 10:7 | 3 | 10 |
| 10 |
|
Argentinos Juniors II | 6 | 3 | 1 | 2 | 6:7 | -1 | 10 |
| 11 |
|
Defensa y Justicia II | 6 | 3 | 1 | 2 | 7:10 | -3 | 10 |
| 12 |
|
Atlético Tucumán II | 6 | 2 | 3 | 1 | 8:5 | 3 | 9 |
| 13 |
|
Sarmiento de Junín II | 6 | 2 | 2 | 2 | 8:9 | -1 | 8 |
| 14 |
|
Talleres de Córdoba II | 6 | 2 | 2 | 2 | 6:8 | -2 | 8 |
| 15 |
|
Boca Juniors II | 6 | 2 | 1 | 3 | 9:7 | 2 | 7 |
| 16 |
|
Unión de Santa Fe II | 6 | 2 | 1 | 3 | 4:6 | -2 | 7 |
| 17 |
|
Newell's Old Boys II | 6 | 2 | 1 | 3 | 8:11 | -3 | 7 |
| 18 |
|
San Lorenzo II | 6 | 2 | 1 | 3 | 6:9 | -3 | 7 |
| 19 |
|
Aldosivi II | 6 | 2 | 0 | 4 | 8:12 | -4 | 6 |
| 20 |
|
Independiente II | 6 | 1 | 2 | 3 | 7:8 | -1 | 5 |
| 21 |
|
Arsenal de Sarandí II | 6 | 1 | 2 | 3 | 6:8 | -2 | 5 |
| 22 |
|
Vélez Sarsfield II | 6 | 1 | 2 | 3 | 3:10 | -7 | 5 |
| 23 |
|
Racing Club II | 6 | 0 | 4 | 2 | 4:7 | -3 | 4 |
| 24 |
|
Huracán II | 6 | 1 | 1 | 4 | 3:6 | -3 | 4 |
| 25 |
|
Godoy Cruz II | 6 | 0 | 3 | 3 | 5:11 | -6 | 3 |
| 26 |
|
Central Córdoba SdE II | 6 | 0 | 0 | 6 | 4:11 | -7 | 0 |
