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| 22.07.2022 | 15:00 | Argentinos Juniors II | - | Banfield II | 0:2 (0:0) | |
| 23.07.2022 | 15:00 | Rosario Central II | - | Arsenal de Sarandí II | 2:1 (1:0) | |
| 15:00 | Racing Club II | - | Central Córdoba SdE II | 0:0 (0:0) | ||
| 15:00 | Atlético Tucumán II | - | Independiente II | 1:2 (0:0) | ||
| 24.07.2022 | 15:00 | Estudiantes II | - | Boca Juniors II | 0:3 (0:1) | |
| 15:00 | Talleres de Córdoba II | - | San Lorenzo II | 1:3 (1:2) | ||
| 15:00 | Colón de Santa Fe II | - | Sarmiento de Junín II | 1:0 (1:0) | ||
| 15:00 | Platense II | - | Tigre II | 1:1 (1:0) | ||
| 15:00 | Defensa y Justicia II | - | Newell's Old Boys II | 1:2 (0:2) | ||
| 25.07.2022 | 15:00 | River Plate II | - | Aldosivi II | 2:0 (0:0) | |
| 15:00 | Huracán II | - | Vélez Sarsfield II | 1:0 (0:0) | ||
| 16:00 | Patronato de Paraná II | - | Barracas Central II | 2:0 (0:0) | ||
| 16:00 | Lanús II | - | Gimnasia de La Plata II | 1:3 (1:1) | ||
| 16:00 | Godoy Cruz II | - | Unión de Santa Fe II | 1:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
River Plate II | 10 | 7 | 0 | 3 | 16:7 | 9 | 21 |
| 2 |
|
Vélez Sarsfield II | 10 | 6 | 1 | 3 | 20:8 | 12 | 19 |
| 3 |
|
Newell's Old Boys II | 10 | 5 | 4 | 1 | 15:9 | 6 | 19 |
| 4 |
|
Rosario Central II | 10 | 5 | 3 | 2 | 22:14 | 8 | 18 |
| 5 |
|
Boca Juniors II | 10 | 6 | 0 | 4 | 16:10 | 6 | 18 |
| 6 |
|
Tigre II | 10 | 5 | 3 | 2 | 12:10 | 2 | 18 |
| 7 |
|
Independiente II | 10 | 5 | 2 | 3 | 17:12 | 5 | 17 |
| 8 |
|
Gimnasia de La Plata II | 10 | 5 | 2 | 3 | 16:11 | 5 | 17 |
| 9 |
|
Huracán II | 10 | 5 | 2 | 3 | 16:15 | 1 | 17 |
| 10 |
|
Racing Club II | 10 | 4 | 4 | 2 | 21:10 | 11 | 16 |
| 11 |
|
Defensa y Justicia II | 10 | 5 | 1 | 4 | 10:11 | -1 | 16 |
| 12 |
|
Argentinos Juniors II | 10 | 4 | 3 | 3 | 13:9 | 4 | 15 |
| 13 |
|
Central Córdoba SdE II | 10 | 4 | 3 | 3 | 11:11 | 0 | 15 |
| 14 |
|
Atlético Tucumán II | 10 | 4 | 2 | 4 | 16:15 | 1 | 14 |
| 15 |
|
San Lorenzo II | 10 | 4 | 2 | 4 | 11:10 | 1 | 14 |
| 16 |
|
Arsenal de Sarandí II | 10 | 3 | 4 | 3 | 8:7 | 1 | 13 |
| 17 |
|
Banfield II | 10 | 4 | 1 | 5 | 9:10 | -1 | 13 |
| 18 |
|
Aldosivi II | 10 | 4 | 1 | 5 | 19:22 | -3 | 13 |
| 19 |
|
Colón de Santa Fe II | 10 | 3 | 4 | 3 | 9:15 | -6 | 13 |
| 20 |
|
Godoy Cruz II | 10 | 3 | 3 | 4 | 12:12 | 0 | 12 |
| 21 |
|
Unión de Santa Fe II | 10 | 3 | 3 | 4 | 10:11 | -1 | 12 |
| 22 |
|
Talleres de Córdoba II | 10 | 3 | 2 | 5 | 13:16 | -3 | 11 |
| 23 |
|
Estudiantes II | 10 | 2 | 3 | 5 | 5:12 | -7 | 9 |
| 24 |
|
Barracas Central II | 10 | 3 | 0 | 7 | 5:15 | -10 | 9 |
| 25 |
|
Sarmiento de Junín II | 10 | 2 | 2 | 6 | 8:17 | -9 | 8 |
| 26 |
|
Patronato de Paraná II | 10 | 2 | 2 | 6 | 8:20 | -12 | 8 |
| 27 |
|
Platense II | 10 | 1 | 4 | 5 | 8:14 | -6 | 7 |
| 28 |
|
Lanús II | 10 | 2 | 1 | 7 | 12:25 | -13 | 7 |
