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| 27.09.2022 | 15:00 | Independiente II | - | Arsenal de Sarandí II | 1:1 (0:1) | |
| 16:00 | Newell's Old Boys II | - | Unión de Santa Fe II | 0:1 (0:0) | ||
| 16:00 | Defensa y Justicia II | - | Platense II | 0:1 (0:0) | ||
| 28.09.2022 | 15:00 | Huracán II | - | San Lorenzo II | 3:1 (2:0) | |
| 16:00 | Gimnasia de La Plata II | - | Barracas Central II | 5:0 (2:0) | ||
| 16:00 | Rosario Central II | - | Racing Club II | 1:1 (0:1) | ||
| 29.09.2022 | 15:00 | River Plate II | - | Argentinos Juniors II | 1:0 (0:0) | |
| 16:00 | Aldosivi II | - | Tigre II | 0:2 (0:0) | ||
| 16:00 | Colón de Santa Fe II | - | Estudiantes II | 3:0 (1:0) | ||
| 16:00 | Atlético Tucumán II | - | Patronato de Paraná II | 0:0 (0:0) | ||
| 30.09.2022 | 15:00 | Vélez Sarsfield II | - | Boca Juniors II | 2:1 (1:0) | |
| 16:00 | Sarmiento de Junín II | - | Central Córdoba SdE II | 2:0 (1:0) | ||
| 16:00 | Godoy Cruz II | - | Banfield II | 3:0 (2:0) | ||
| 16:00 | Lanús II | - | Talleres de Córdoba II | 3:2 (2:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors II | 22 | 13 | 3 | 6 | 37:18 | 19 | 42 |
| 2 |
|
Vélez Sarsfield II | 22 | 13 | 2 | 7 | 37:16 | 21 | 41 |
| 3 |
|
Huracán II | 22 | 12 | 3 | 7 | 46:34 | 12 | 39 |
| 4 |
|
Tigre II | 22 | 11 | 6 | 5 | 28:22 | 6 | 39 |
| 5 |
|
Newell's Old Boys II | 22 | 10 | 7 | 5 | 30:22 | 8 | 37 |
| 6 |
|
River Plate II | 22 | 12 | 1 | 9 | 24:22 | 2 | 37 |
| 7 |
|
Gimnasia de La Plata II | 22 | 10 | 6 | 6 | 41:27 | 14 | 36 |
| 8 |
|
Argentinos Juniors II | 22 | 9 | 9 | 4 | 30:19 | 11 | 36 |
| 9 |
|
Independiente II | 22 | 10 | 5 | 7 | 36:27 | 9 | 35 |
| 10 |
|
Defensa y Justicia II | 22 | 10 | 4 | 8 | 25:23 | 2 | 34 |
| 11 |
|
Lanús II | 22 | 10 | 4 | 8 | 35:36 | -1 | 34 |
| 12 |
|
Rosario Central II | 22 | 8 | 7 | 7 | 35:31 | 4 | 31 |
| 13 |
|
Talleres de Córdoba II | 22 | 9 | 4 | 9 | 34:30 | 4 | 31 |
| 14 |
|
San Lorenzo II | 22 | 9 | 3 | 10 | 27:28 | -1 | 30 |
| 15 |
|
Banfield II | 22 | 8 | 6 | 8 | 22:23 | -1 | 30 |
| 16 |
|
Colón de Santa Fe II | 22 | 7 | 8 | 7 | 30:31 | -1 | 29 |
| 17 |
|
Unión de Santa Fe II | 22 | 7 | 8 | 7 | 20:21 | -1 | 29 |
| 18 |
|
Godoy Cruz II | 22 | 7 | 7 | 8 | 29:28 | 1 | 28 |
| 19 |
|
Arsenal de Sarandí II | 22 | 6 | 9 | 7 | 22:22 | 0 | 27 |
| 20 |
|
Estudiantes II | 22 | 6 | 9 | 7 | 19:23 | -4 | 27 |
| 21 |
|
Platense II | 22 | 5 | 11 | 6 | 20:22 | -2 | 26 |
| 22 |
|
Central Córdoba SdE II | 22 | 7 | 4 | 11 | 21:34 | -13 | 25 |
| 23 |
|
Sarmiento de Junín II | 22 | 7 | 3 | 12 | 18:34 | -16 | 24 |
| 24 |
|
Atlético Tucumán II | 22 | 6 | 5 | 11 | 28:35 | -7 | 23 |
| 25 |
|
Racing Club II | 22 | 5 | 7 | 10 | 28:28 | 0 | 22 |
| 26 |
|
Patronato de Paraná II | 22 | 5 | 5 | 12 | 17:35 | -18 | 20 |
| 27 |
|
Barracas Central II | 22 | 6 | 1 | 15 | 15:43 | -28 | 19 |
| 28 |
|
Aldosivi II | 22 | 5 | 3 | 14 | 26:46 | -20 | 18 |
