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| 28.08.2021 | 11:00 | SV Wehen Wiesbaden | - | Darmstadt | 3:1 (1:0) | |
| 12:30 | Stuttgart | - | SC Freiburg | 3:2 (1:2) | ||
| 12:30 | Karlsruher SC | - | 1. FC Kaiserslautern | 2:0 (1:0) | ||
| 13:00 | SV 07 Elversberg | - | Eintracht Frankfurt | 0:4 (0:3) | ||
| 13:00 | 1. FC Nürnberg | - | Augsburgo | 2:3 (2:1) | ||
| 13:30 | Mainz | - | SSV Reutlingen | 5:0 (2:0) | ||
| 14:00 | Hoffenheim | - | 1. FC Heidenheim 1846 | 8:2 (3:1) | ||
| 29.09.2021 | 19:00 | SpVgg Unterhaching | - | Ingolstadt | 5:0 (0:0) | |
| 16.10.2021 | 11:30 | Bayern Múnich | - | Stuttgarter Kickers | 6:1 (3:0) | |
| 24.10.2021 | 13:00 | FSV Frankfurt | - | SpVgg Greuther Fürth | 1:2 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SpVgg Unterhaching | 3 | 3 | 0 | 0 | 11:3 | 8 | 9 |
| 2 |
|
Mainz | 3 | 2 | 1 | 0 | 11:2 | 9 | 7 |
| 3 |
|
Stuttgart | 3 | 2 | 1 | 0 | 10:3 | 7 | 7 |
| 4 |
|
Eintracht Frankfurt | 3 | 2 | 1 | 0 | 8:1 | 7 | 7 |
| 5 |
|
SC Freiburg | 3 | 2 | 0 | 1 | 8:3 | 5 | 6 |
| 6 |
|
Hoffenheim | 3 | 2 | 0 | 1 | 12:8 | 4 | 6 |
| 7 |
|
FSV Frankfurt | 3 | 2 | 0 | 1 | 5:3 | 2 | 6 |
| 8 |
|
TSV 1860 München | 2 | 1 | 1 | 0 | 5:4 | 1 | 4 |
| 9 |
|
Karlsruher SC | 3 | 1 | 1 | 1 | 4:3 | 1 | 4 |
| 10 |
|
SpVgg Greuther Fürth | 3 | 1 | 1 | 1 | 5:5 | 0 | 4 |
| 11 |
|
Bayern Múnich | 2 | 1 | 0 | 1 | 6:3 | 3 | 3 |
| 12 |
|
1. FC Kaiserslautern | 3 | 1 | 0 | 2 | 7:5 | 2 | 3 |
| 13 |
|
1. FC Nürnberg | 3 | 1 | 0 | 2 | 6:6 | 0 | 3 |
| 14 |
|
Augsburgo | 3 | 1 | 0 | 2 | 5:8 | -3 | 3 |
| 15 |
|
SV Wehen Wiesbaden | 3 | 1 | 0 | 2 | 3:6 | -3 | 3 |
| 16 |
|
Darmstadt | 3 | 1 | 0 | 2 | 4:8 | -4 | 3 |
| 17 |
|
Stuttgarter Kickers | 3 | 1 | 0 | 2 | 5:10 | -5 | 3 |
| 18 |
|
SV 07 Elversberg | 3 | 1 | 0 | 2 | 3:9 | -6 | 3 |
| 19 |
|
1. FC Heidenheim 1846 | 2 | 0 | 1 | 1 | 4:10 | -6 | 1 |
| 20 |
|
Ingolstadt | 3 | 0 | 1 | 2 | 1:10 | -9 | 1 |
| 21 |
|
SSV Reutlingen | 3 | 0 | 0 | 3 | 1:14 | -13 | 0 |
| Playoff | |
| Descenso |
