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| I | Gante | - | Club Brugge KV | 0:1 (0:0) | ||
| V | Club Brugge KV | - | Gante | 0:3 (0:2) | ||
| I: 02.02.2022 20:45 | V: 02.03.2022 20:45 | Campeones: Gante | ||||
| I | KAS Eupen | - | RSC Anderlecht | 2:2 (1:1) | ||
| V | RSC Anderlecht | - | KAS Eupen | 3:1 (2:1) | ||
| I: 03.02.2022 20:45 | V: 03.03.2022 20:45 | Campeones: RSC Anderlecht | ||||
