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| 25.02.2022 | 20:00 | CD Guabirá | - | Nacional Potosí | 1:3 (2:0) | |
| 26.02.2022 | 01:00 | Blooming | - | Universitario de Vinto | 5:0 (3:0) | |
| 20:00 | Real Santa Cruz | - | The Strongest | 1:2 (0:1) | ||
| 20:00 | Atlético Palmaflor | - | Oriente Petrolero | 2:1 (2:0) | ||
| 22:15 | Real Tomayapo | - | Royal Pari | 1:0 (1:0) | ||
| 27.02.2022 | 20:00 | Universitario de Sucre | - | Club Aurora | 1:1 (0:0) | |
| 22:15 | Bolívar | - | Always Ready | 3:0 (0:0) | ||
| 28.02.2022 | 00:15 | Jorge Wilstermann | - | Independiente Petrolero | 1:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
The Strongest | 4 | 3 | 1 | 0 | 8:2 | 6 | 10 |
| 2 |
|
Universitario de Sucre | 4 | 2 | 2 | 0 | 7:5 | 2 | 8 |
| 3 |
|
Nacional Potosí | 4 | 2 | 1 | 1 | 8:6 | 2 | 7 |
| 4 |
|
Atlético Palmaflor | 4 | 2 | 1 | 1 | 5:6 | -1 | 7 |
| 5 |
|
Oriente Petrolero | 4 | 2 | 0 | 2 | 5:5 | 0 | 6 |
| 6 |
|
CD Guabirá | 4 | 0 | 2 | 2 | 4:7 | -3 | 2 |
| 7 |
|
Club Aurora | 4 | 0 | 2 | 2 | 2:5 | -3 | 2 |
| 8 |
|
Real Santa Cruz | 4 | 0 | 1 | 3 | 3:6 | -3 | 1 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bolívar | 4 | 3 | 0 | 1 | 12:1 | 11 | 9 |
| 2 |
|
Real Tomayapo | 4 | 2 | 2 | 0 | 4:2 | 2 | 8 |
| 3 |
|
Blooming | 4 | 2 | 1 | 1 | 7:8 | -1 | 7 |
| 4 |
|
Jorge Wilstermann | 4 | 2 | 0 | 2 | 3:3 | 0 | 6 |
| 5 |
|
Independiente Petrolero | 4 | 1 | 1 | 2 | 3:4 | -1 | 4 |
| 6 |
|
Always Ready | 4 | 1 | 1 | 2 | 4:7 | -3 | 4 |
| 7 |
|
Universitario de Vinto | 4 | 1 | 1 | 2 | 3:8 | -5 | 4 |
| 8 |
|
Royal Pari | 4 | 0 | 2 | 2 | 3:6 | -3 | 2 |
| Playoff | |
| Playoff |
