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| 20.05.2022 | 02:00 | CD Guabirá | - | Universitario de Sucre | 1:0 (0:0) | |
| 21.05.2022 | 21:00 | Real Santa Cruz | - | Atlético Palmaflor | 1:2 (0:0) | |
| 21:00 | Nacional Potosí | - | Oriente Petrolero | 4:2 (2:1) | ||
| 21:00 | The Strongest | - | Club Aurora | 1:0 (1:0) | ||
| 23:15 | Independiente Petrolero | - | Royal Pari | 0:0 (0:0) | ||
| 22.05.2022 | 21:00 | Universitario de Vinto | - | Always Ready | 2:1 (0:1) | |
| 21:00 | Blooming | - | Real Tomayapo | 2:1 (0:1) | ||
| 21:00 | Jorge Wilstermann | - | Bolívar | 1:4 (0:3) |
| » Clasificación | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Palmaflor | 16 | 9 | 1 | 6 | 18:21 | -3 | 28 |
| 2 |
|
The Strongest | 16 | 7 | 6 | 3 | 21:11 | 10 | 27 |
| 3 |
|
Nacional Potosí | 16 | 7 | 4 | 5 | 31:24 | 7 | 25 |
| 4 |
|
Oriente Petrolero | 16 | 6 | 4 | 6 | 22:22 | 0 | 22 |
| 5 |
|
CD Guabirá | 16 | 5 | 4 | 7 | 17:21 | -4 | 19 |
| 6 |
|
Real Santa Cruz | 16 | 5 | 3 | 8 | 22:28 | -6 | 18 |
| 7 |
|
Club Aurora | 16 | 4 | 5 | 7 | 18:21 | -3 | 17 |
| 8 |
|
Universitario de Sucre | 16 | 4 | 4 | 8 | 17:22 | -5 | 16 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bolívar | 16 | 12 | 1 | 3 | 42:9 | 33 | 37 |
| 2 |
|
Blooming | 16 | 8 | 3 | 5 | 27:30 | -3 | 27 |
| 3 |
|
Royal Pari | 16 | 6 | 5 | 5 | 32:26 | 6 | 23 |
| 4 |
|
Always Ready | 16 | 5 | 4 | 7 | 24:22 | 2 | 19 |
| 5 |
|
Universitario de Vinto | 16 | 5 | 4 | 7 | 18:29 | -11 | 19 |
| 6 |
|
Jorge Wilstermann | 16 | 4 | 6 | 6 | 16:20 | -4 | 18 |
| 7 |
|
Independiente Petrolero | 16 | 4 | 6 | 6 | 17:26 | -9 | 18 |
| 8 |
|
Real Tomayapo | 16 | 4 | 6 | 6 | 14:24 | -10 | 18 |
| Playoff | |
| Playoff |
