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| 20.11.2010 | 12:30 | Vihren Sandanski | - | PSFC Chernomorets | 0:5 (0:3) | |
| 12:30 | PFC Chavdar Byala Slatina | - | Etar Veliko Tarnovo | 2:4 (0:0, 0:0, 0:0) pn. | ||
| 12:30 | FK Dobrudzha | - | Botev Vratsa | 1:0 (1:0) | ||
| 12:30 | PFC Montana | - | Cherno More Varna | 0:1 (0:1) | ||
| 12:30 | Minyor Pernik | - | Akademik Sofia | 3:2 (0:1, 1:1, 1:1) pn. | ||
| 12:30 | PFC Bansko | - | Levski Sofia | 1:3 (0:2) | ||
| 12:30 | FK Chavdar | - | PFC Beroe | 0:1 (0:1) | ||
| 12:30 | Botev Krivodol | - | Kom-Minyor | 0:2 (0:0, 0:0) pró. | ||
| 12:30 | Chernomorets Balchik | - | PFC Litex Lovech | 1:2 (0:1) | ||
| 12:30 | FK Malesh Mikrevo | - | Vidima Rakovski | 5:4 (0:0, 0:0, 0:0) pn. | ||
| 12:30 | FK Sozopol | - | PFC Kaliakra Kavarna | 0:1 (0:1) | ||
| 12:30 | FK Dorostol 2003 | - | Pirin Blagoevgrad | 3:5 (0:0, 0:0, 0:0) pn. | ||
| 12:30 | PFC Ludogorets Razgrad | - | Slavia Sofia | 0:2 (0:2) | ||
| 12:30 | FK Topolite | - | PFC Chernomorets Pomorie | 0:1 (0:1) | ||
| 13:00 | OFC Sliven | - | CSKA Sofia | 1:3 (1:0) | ||
| 21.11.2010 | 13:00 | Lokomotiv Sofia | - | Lokomotiv Plovdiv | 3:4 pn. |
