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| I | Young Buffaloes | - | AS Vita Club | 2:2 (1:0) | ||
| V | AS Vita Club | - | Young Buffaloes | 4:1 (1:0) | ||
| I: 22.12.2020 14:00 | V: 06.01.2021 15:30 | Campeones: AS Vita Club | ||||
| I | Jwaneng Galaxy | - | Mamelodi Sundowns | 0:2 (0:1) | ||
| V | Mamelodi Sundowns | - | Jwaneng Galaxy | 3:1 (1:0) | ||
| I: 22.12.2020 14:30 | V: 05.01.2021 15:30 | Campeones: Mamelodi Sundowns | ||||
| I | Teungueth FC | - | Raja Casablanca | 0:0 (0:0) | ||
| V | Raja Casablanca | - | Teungueth FC | 1:3 (0:0, 0:0) pn. | ||
| I: 22.12.2020 18:00 | V: 05.01.2021 19:00 | Campeones: Teungueth FC | ||||
| I | Gazelle FC | - | Zamalek | no jug. | ||
| V | Zamalek | - | Gazelle FC | no jug. | ||
| I: 23.12.2020 | V: 06.01.2021 | Campeones: Gazelle FC | ||||
| I | Al Merrikh SC | - | Enyimba Aba | 3:0 (2:0) | ||
| V | Enyimba Aba | - | Al Merrikh SC | 2:1 (1:1) | ||
| I: 23.12.2020 14:00 | V: 06.01.2021 15:30 | Campeones: Al Merrikh SC | ||||
| I | Nkana FC | - | Petro Atlético | 1:1 (0:0) | ||
| V | Petro Atlético | - | Nkana FC | 1:0 (0:0) | ||
| I: 23.12.2020 14:00 | V: 06.01.2021 17:00 | Campeones: Petro Atlético | ||||
| I | FC Platinum | - | Simba SC | 1:0 (1:0) | ||
| V | Simba SC | - | FC Platinum | 4:0 (1:0) | ||
| I: 23.12.2020 14:00 | V: 06.01.2021 15:00 | Campeones: Simba SC | ||||
| I | AS SONIDEP | - | Al Ahly SC | 0:1 (0:1) | ||
| V | Al Ahly SC | - | AS SONIDEP | 4:0 (2:0) | ||
| I: 23.12.2020 15:00 | V: 05.01.2021 18:00 | Campeones: Al Ahly SC | ||||
| I | AS Bouenguidi | - | TP Mazembe | 1:2 (1:1) | ||
| V | TP Mazembe | - | AS Bouenguidi | 2:1 (2:0) | ||
| I: 23.12.2020 15:30 | V: 06.01.2021 14:30 | Campeones: TP Mazembe | ||||
| I | Asante Kotoko | - | Al Hilal Omdurman | 0:1 (0:0) | ||
| V | Al Hilal Omdurman | - | Asante Kotoko | 2:0 | ||
| I: 23.12.2020 16:00 | V: 06.01.2021 14:00 | Campeones: Al Hilal Omdurman | ||||
| I | Stade Malien | - | Wydad AC | 1:0 (0:0) | ||
| V | Wydad AC | - | Stade Malien | 3:0 (1:0) | ||
| I: 23.12.2020 17:00 | V: 06.01.2021 17:00 | Campeones: Wydad AC | ||||
| I | RC Abidjan | - | Horoya AC | 1:1 (0:1) | ||
| V | Horoya AC | - | RC Abidjan | 1:0 (0:0) | ||
| I: 23.12.2020 17:00 | V: 06.01.2021 17:00 | Campeones: Horoya AC | ||||
| I | Al Ahly Benghazi | - | Espérance de Tunis | 0:0 (0:0) | ||
| V | Espérance de Tunis | - | Al Ahly Benghazi | 3:2 (1:0) | ||
| I: 23.12.2020 17:00 | V: 06.01.2021 15:00 | Campeones: Espérance de Tunis | ||||
| I | Kaizer Chiefs | - | CD 1º de Agosto | 0:0 (0:0) | ||
| V | CD 1º de Agosto | - | Kaizer Chiefs | 0:1 (0:1) | ||
| I: 23.12.2020 17:00 | V: 05.01.2021 16:00 | Campeones: Kaizer Chiefs | ||||
| I | CR Bélouizdad | - | Gor Mahia FC | 6:0 (4:0) | ||
| V | Gor Mahia FC | - | CR Bélouizdad | 1:2 (1:0) | ||
| I: 26.12.2020 20:45 | V: 06.01.2021 13:00 | Campeones: CR Bélouizdad | ||||
| I | MC Alger | - | CS Sfaxien | 2:0 (2:0) | ||
| V | CS Sfaxien | - | MC Alger | 1:0 (1:0) | ||
| I: 28.12.2020 20:45 | V: 06.01.2021 15:00 | Campeones: MC Alger | ||||
