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| I | New York RB | - | Santos Laguna | 0:2 (0:1) | ||
| V | Santos Laguna | - | New York RB | 4:2 (0:2) | ||
| I: 06.03.2019 02:00 | V: 13.03.2019 02:00 | Campeones: Santos Laguna | ||||
| I | Houston Dynamo | - | UANL Tigres | 0:2 (0:0) | ||
| V | UANL Tigres | - | Houston Dynamo | 1:0 (0:0) | ||
| I: 06.03.2019 04:00 | V: 13.03.2019 04:00 | Campeones: UANL Tigres | ||||
| I | Independiente de La Chorrera | - | Sporting Kansas City | 2:1 (1:0) | ||
| V | Sporting Kansas City | - | Independiente de La Chorrera | 3:0 (0:0) | ||
| I: 07.03.2019 02:00 | V: 15.03.2019 01:00 | Campeones: Sporting Kansas City | ||||
| I | CF Monterrey | - | Atlanta United FC | 3:0 (1:0) | ||
| V | Atlanta United FC | - | CF Monterrey | 1:0 (0:0) | ||
| I: 07.03.2019 04:00 | V: 14.03.2019 01:00 | Campeones: CF Monterrey | ||||
