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| I | Karmiotissa Polemidion | - | Anorthosis Famagusta | 1:2 (0:1) | ||
| V | Anorthosis Famagusta | - | Karmiotissa Polemidion | 5:1 (3:0) | ||
| I: 24.02.2021 15:00 | V: 10.03.2021 17:00 | Campeones: Anorthosis Famagusta | ||||
| I | APOEL Nikosia | - | Omonia Nikosia | 1:1 (0:0) | ||
| V | Omonia Nikosia | - | APOEL Nikosia | 0:1 (0:0) | ||
| I: 24.02.2021 17:30 | V: 10.03.2021 15:00 | Campeones: APOEL Nikosia | ||||
| I | AEL Limassol | - | Nea Salamina | 2:0 (0:0) | ||
| V | Nea Salamina | - | AEL Limassol | 1:0 (0:0) | ||
| I: 03.03.2021 16:00 | V: 17.03.2021 17:00 | Campeones: AEL Limassol | ||||
| I | Ethnikos Achna | - | Olympiacos Nikosia | 1:1 (0:1) | ||
| V | Olympiacos Nikosia | - | Ethnikos Achna | 1:0 (0:0) | ||
| I: 03.03.2021 18:00 | V: 17.03.2021 15:00 | Campeones: Olympiacos Nikosia | ||||
