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| 02.04.2022 | 14:00 | Getafe | - | Mallorca | 1:0 (0:0) | |
| 16:15 | Levante | - | Villarreal | 2:0 (0:0) | ||
| 18:30 | Celta | - | Real Madrid | 1:2 (0:1) | ||
| 21:00 | Atlético | - | Alavés | 4:1 (1:0) | ||
| 03.04.2022 | 14:00 | Athletic | - | Elche | 2:1 (1:0) | |
| 16:15 | Betis | - | Osasuna | 4:1 (2:0) | ||
| 18:30 | Granada | - | Rayo | 2:2 (0:2) | ||
| 18:30 | Valencia | - | Cádiz CF | 0:0 (0:0) | ||
| 21:00 | Barcelona | - | Sevilla | 1:0 (0:0) | ||
| 04.04.2022 | 21:00 | Real Sociedad | - | Espanyol | 1:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Real Madrid | 30 | 21 | 6 | 3 | 61:26 | 35 | 69 |
| 2 |
|
Barcelona | 30 | 16 | 9 | 5 | 57:30 | 27 | 57 |
| 3 |
|
Atlético | 30 | 17 | 6 | 7 | 57:37 | 20 | 57 |
| 4 |
|
Sevilla | 30 | 15 | 12 | 3 | 40:20 | 20 | 57 |
| 5 |
|
Betis | 30 | 16 | 5 | 9 | 54:36 | 18 | 53 |
| 6 |
|
Real Sociedad | 30 | 14 | 9 | 7 | 30:29 | 1 | 51 |
| 7 |
|
Villarreal | 30 | 12 | 9 | 9 | 48:29 | 19 | 45 |
| 8 |
|
Athletic | 30 | 11 | 11 | 8 | 35:29 | 6 | 44 |
| 9 |
|
Valencia | 30 | 10 | 11 | 9 | 42:43 | -1 | 41 |
| 10 |
|
Osasuna | 30 | 10 | 8 | 12 | 30:40 | -10 | 38 |
| 11 |
|
Celta | 30 | 9 | 9 | 12 | 34:34 | 0 | 36 |
| 12 |
|
Rayo | 30 | 10 | 6 | 14 | 32:36 | -4 | 36 |
| 13 |
|
Espanyol | 30 | 9 | 9 | 12 | 35:42 | -7 | 36 |
| 14 |
|
Getafe | 30 | 7 | 11 | 12 | 28:33 | -5 | 32 |
| 15 |
|
Elche | 30 | 8 | 8 | 14 | 31:42 | -11 | 32 |
| 16 |
|
Granada | 30 | 6 | 11 | 13 | 33:48 | -15 | 29 |
| 17 |
|
Cádiz CF | 30 | 5 | 13 | 12 | 25:41 | -16 | 28 |
| 18 |
|
Mallorca | 30 | 6 | 8 | 16 | 26:50 | -24 | 26 |
| 19 |
|
Levante | 30 | 4 | 10 | 16 | 33:58 | -25 | 22 |
| 20 |
|
Alavés | 30 | 5 | 7 | 18 | 24:52 | -28 | 22 |
| Champions League | |
| Europa League | |
| ECL Ronda previa | |
| Descenso |
