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| 20.11.2022 | 11:30 | Sevilla Atlético | - | Mar Menor CF | 2:2 (1:2) | |
| 12:00 | Utrera CD | - | RC Recreativo | 0:0 (0:0) | ||
| 12:00 | Atlético Mancha Real | - | Antequera CF | 1:2 (0:1) | ||
| 12:00 | CD San Roque | - | Betis B | 1:0 (0:0) | ||
| 12:00 | Vélez CF | - | Granada B | 1:0 (1:0) | ||
| 17:00 | Juventud Torremolinos | - | CD El Ejido 2012 | 0:1 (0:1) | ||
| 17:00 | UCAM Murcia CF | - | Cádiz CF B | 2:1 (1:1) | ||
| 17:00 | Xerez DFC | - | FC Cartagena B | 0:2 (0:2) | ||
| 17:00 | Yeclano Deportivo | - | Atlético Sanluqueño CF | 3:1 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Antequera CF | 11 | 8 | 2 | 1 | 19:7 | 12 | 26 |
| 2 |
|
RC Recreativo | 11 | 6 | 3 | 2 | 12:10 | 2 | 21 |
| 3 |
|
Mar Menor CF | 11 | 6 | 2 | 3 | 16:11 | 5 | 20 |
| 4 |
|
Yeclano Deportivo | 11 | 5 | 4 | 2 | 14:10 | 4 | 19 |
| 5 |
|
Cádiz CF B | 11 | 5 | 3 | 3 | 15:10 | 5 | 18 |
| 6 |
|
Vélez CF | 11 | 5 | 2 | 4 | 12:11 | 1 | 17 |
| 7 |
|
UCAM Murcia CF | 11 | 4 | 4 | 3 | 13:9 | 4 | 16 |
| 8 |
|
Betis B | 11 | 4 | 4 | 3 | 11:10 | 1 | 16 |
| 9 |
|
Atlético Sanluqueño CF | 11 | 4 | 4 | 3 | 11:11 | 0 | 16 |
| 10 |
|
CD San Roque | 11 | 4 | 2 | 5 | 11:10 | 1 | 14 |
| 11 |
|
FC Cartagena B | 11 | 4 | 2 | 5 | 10:11 | -1 | 14 |
| 12 |
|
CD El Ejido 2012 | 11 | 4 | 1 | 6 | 9:12 | -3 | 13 |
| 13 |
|
Atlético Mancha Real | 11 | 3 | 4 | 4 | 8:11 | -3 | 13 |
| 14 |
|
Utrera CD | 11 | 3 | 3 | 5 | 12:16 | -4 | 12 |
| 15 |
|
Xerez DFC | 11 | 2 | 5 | 4 | 8:13 | -5 | 11 |
| 16 |
|
Juventud Torremolinos | 11 | 1 | 7 | 3 | 5:9 | -4 | 10 |
| 17 |
|
Sevilla Atlético | 11 | 2 | 1 | 8 | 10:16 | -6 | 7 |
| 18 |
|
Granada B | 11 | 1 | 3 | 7 | 9:18 | -9 | 6 |
| Ascenso | |
| Playoff | |
| Descenso |
