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| I | PAOK Saloniki | - | Gante | 1:0 (0:0) | ||
| V | Gante | - | PAOK Saloniki | 1:2 (1:1) | ||
| I: 10.03.2022 18:45 | V: 17.03.2022 21:00 | Campeones: PAOK Saloniki | ||||
| I | Vitesse | - | Roma | 0:1 (0:1) | ||
| V | Roma | - | Vitesse | 1:1 (0:0) | ||
| I: 10.03.2022 18:45 | V: 17.03.2022 21:00 | Campeones: Roma | ||||
| I | Slavia Praga | - | LASK | 4:1 (2:0) | ||
| V | LASK | - | Slavia Praga | 4:3 (1:2) | ||
| I: 10.03.2022 18:45 | V: 17.03.2022 21:00 | Campeones: Slavia Praga | ||||
| I | Partizan | - | Feyenoord | 2:5 (1:1) | ||
| V | Feyenoord | - | Partizan | 3:1 (1:0) | ||
| I: 10.03.2022 18:45 | V: 17.03.2022 21:00 | Campeones: Feyenoord | ||||
| I | Marsella | - | Basilea | 2:1 (1:0) | ||
| V | Basilea | - | Marsella | 1:2 (0:0) | ||
| I: 10.03.2022 21:00 | V: 17.03.2022 18:45 | Campeones: Marsella | ||||
| I | Leicester City | - | Rennes | 2:0 (1:0) | ||
| V | Rennes | - | Leicester City | 2:1 (1:0) | ||
| I: 10.03.2022 21:00 | V: 17.03.2022 18:45 | Campeones: Leicester City | ||||
| I | PSV | - | FC København | 4:4 (1:3) | ||
| V | FC København | - | PSV | 0:4 (0:2) | ||
| I: 10.03.2022 21:00 | V: 17.03.2022 18:45 | Campeones: PSV | ||||
| I | FK Bodø/Glimt | - | AZ Alkmaar | 2:1 (1:0) | ||
| V | AZ Alkmaar | - | FK Bodø/Glimt | 2:2 (2:1, 2:1) pró. | ||
| I: 10.03.2022 21:00 | V: 17.03.2022 18:45 | Campeones: FK Bodø/Glimt | ||||
