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| I | AFC Ajax | - | BSC Young Boys | 3:0 (0:0) | ||
| V | BSC Young Boys | - | AFC Ajax | 0:2 (0:1) | ||
| I: 11.03.2021 18:55 | V: 18.03.2021 21:00 | Campeones: AFC Ajax | ||||
| I | Dinamo Kiev | - | Villarreal | 0:2 (0:1) | ||
| V | Villarreal | - | Dinamo Kiev | 2:0 (2:0) | ||
| I: 11.03.2021 18:55 | V: 18.03.2021 21:00 | Campeones: Villarreal | ||||
| I | Manchester United | - | Milan | 1:1 (0:0) | ||
| V | Milan | - | Manchester United | 0:1 (0:0) | ||
| I: 11.03.2021 18:55 | V: 18.03.2021 21:00 | Campeones: Manchester United | ||||
| I | Slavia Praga | - | Rangers FC | 1:1 (1:1) | ||
| V | Rangers FC | - | Slavia Praga | 0:2 (0:1) | ||
| I: 11.03.2021 18:55 | V: 18.03.2021 21:00 | Campeones: Slavia Praga | ||||
| I | Roma | - | Shakhtar Donetsk | 3:0 (1:0) | ||
| V | Shakhtar Donetsk | - | Roma | 1:2 (0:0) | ||
| I: 11.03.2021 21:00 | V: 18.03.2021 18:55 | Campeones: Roma | ||||
| I | Olympiacos | - | Arsenal | 1:3 (0:1) | ||
| V | Arsenal | - | Olympiacos | 0:1 (0:0) | ||
| I: 11.03.2021 21:00 | V: 18.03.2021 18:55 | Campeones: Arsenal | ||||
| I | Tottenham Hotspur | - | Dinamo Zagreb | 2:0 (1:0) | ||
| V | Dinamo Zagreb | - | Tottenham Hotspur | 3:0 (0:0, 2:0, 3:0) pró. | ||
| I: 11.03.2021 21:00 | V: 18.03.2021 18:55 | Campeones: Dinamo Zagreb | ||||
| I | Granada | - | Molde FK | 2:0 (1:0) | ||
| V | Molde FK | - | Granada | 2:1 (1:0) | ||
| I: 11.03.2021 21:00 | V: 18.03.2021 18:55 | Campeones: Granada | ||||
