 |
 |
|
|
| I | Barcelona | - | Nápoles | 1:1 (0:1) | ||
| V | Nápoles | - | Barcelona | 2:4 (1:3) | ||
| I: 17.02.2022 18:45 | V: 24.02.2022 21:00 | Campeones: Barcelona | ||||
| I | Zenit | - | Betis | 2:3 (2:3) | ||
| V | Betis | - | Zenit | 0:0 (0:0) | ||
| I: 17.02.2022 18:45 | V: 24.02.2022 21:00 | Campeones: Betis | ||||
| I | Borussia Dortmund | - | Rangers FC | 2:4 (0:2) | ||
| V | Rangers FC | - | Borussia Dortmund | 2:2 (1:2) | ||
| I: 17.02.2022 18:45 | V: 24.02.2022 21:00 | Campeones: Rangers FC | ||||
| I | FC Sheriff | - | Sporting Braga | 2:0 (1:0) | ||
| V | Sporting Braga | - | FC Sheriff | 3:2 (2:0, 2:0, 2:0) pn. | ||
| I: 17.02.2022 18:45 | V: 24.02.2022 21:00 | Campeones: Sporting Braga | ||||
| I | Sevilla | - | Dinamo Zagreb | 3:1 (3:1) | ||
| V | Dinamo Zagreb | - | Sevilla | 1:0 (0:0) | ||
| I: 17.02.2022 21:00 | V: 24.02.2022 18:45 | Campeones: Sevilla | ||||
| I | Atalanta | - | Olympiacos | 2:1 (0:1) | ||
| V | Olympiacos | - | Atalanta | 0:3 (0:1) | ||
| I: 17.02.2022 21:00 | V: 24.02.2022 18:45 | Campeones: Atalanta | ||||
| I | RB Leipzig | - | Real Sociedad | 2:2 (1:1) | ||
| V | Real Sociedad | - | RB Leipzig | 1:3 (0:1) | ||
| I: 17.02.2022 21:00 | V: 24.02.2022 18:45 | Campeones: RB Leipzig | ||||
| I | Oporto | - | Lazio | 2:1 (1:1) | ||
| V | Lazio | - | Oporto | 2:2 (1:1) | ||
| I: 17.02.2022 21:00 | V: 24.02.2022 18:45 | Campeones: Oporto | ||||
