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| I | RB Leipzig | - | Atalanta | 1:1 (0:1) | ||
| V | Atalanta | - | RB Leipzig | 0:2 (0:1) | ||
| I: 07.04.2022 18:45 | V: 14.04.2022 18:45 | Campeones: RB Leipzig | ||||
| I | Eintracht Frankfurt | - | Barcelona | 1:1 (0:0) | ||
| V | Barcelona | - | Eintracht Frankfurt | 2:3 (0:2) | ||
| I: 07.04.2022 21:00 | V: 14.04.2022 21:00 | Campeones: Eintracht Frankfurt | ||||
| I | West Ham United | - | Lyon | 1:1 (0:0) | ||
| V | Lyon | - | West Ham United | 0:3 (0:2) | ||
| I: 07.04.2022 21:00 | V: 14.04.2022 21:00 | Campeones: West Ham United | ||||
| I | Sporting Braga | - | Rangers FC | 1:0 (1:0) | ||
| V | Rangers FC | - | Sporting Braga | 3:1 (2:0, 2:1) pró. | ||
| I: 07.04.2022 21:00 | V: 14.04.2022 21:00 | Campeones: Rangers FC | ||||
