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| I | Crvena Zvezda | - | CFR Cluj | 4:0 (2:0) | ||
| V | CFR Cluj | - | Crvena Zvezda | 1:2 (1:1) | ||
| I: 17.08.2021 21:00 | V: 26.08.2021 20:30 | Campeones: Crvena Zvezda | ||||
| I | Celtic FC | - | AZ Alkmaar | 2:0 (1:0) | ||
| V | AZ Alkmaar | - | Celtic FC | 2:1 (2:1) | ||
| I: 18.08.2021 20:45 | V: 26.08.2021 20:15 | Campeones: Celtic FC | ||||
| I | Randers FC | - | Galatasaray | 1:1 (0:1) | ||
| V | Galatasaray | - | Randers FC | 2:1 (0:1) | ||
| I: 19.08.2021 19:00 | V: 26.08.2021 20:00 | Campeones: Galatasaray | ||||
| I | Omonia Nikosia | - | Royal Antwerp FC | 4:2 (1:1) | ||
| V | Royal Antwerp FC | - | Omonia Nikosia | 3:2 (1:0, 2:0, 2:0) pn. | ||
| I: 19.08.2021 19:00 | V: 26.08.2021 21:00 | Campeones: Royal Antwerp FC | ||||
| I | Slavia Praga | - | Legia Warszawa | 2:2 (2:2) | ||
| V | Legia Warszawa | - | Slavia Praga | 2:1 (0:1) | ||
| I: 19.08.2021 19:00 | V: 26.08.2021 21:00 | Campeones: Legia Warszawa | ||||
| I | NŠ Mura | - | Sturm Graz | 1:3 (1:1) | ||
| V | Sturm Graz | - | NŠ Mura | 2:0 (1:0) | ||
| I: 19.08.2021 20:00 | V: 26.08.2021 21:00 | Campeones: Sturm Graz | ||||
| I | Fenerbahçe | - | HJK Helsinki | 1:0 (0:0) | ||
| V | HJK Helsinki | - | Fenerbahçe | 2:5 (1:2) | ||
| I: 19.08.2021 20:45 | V: 26.08.2021 18:00 | Campeones: Fenerbahçe | ||||
| I | Rapid Wien | - | Zorya Lugansk | 3:0 (1:0) | ||
| V | Zorya Lugansk | - | Rapid Wien | 2:3 (1:2) | ||
| I: 19.08.2021 21:00 | V: 26.08.2021 18:30 | Campeones: Rapid Wien | ||||
| I | Olympiacos | - | Slovan Bratislava | 3:0 (1:0) | ||
| V | Slovan Bratislava | - | Olympiacos | 2:2 (1:1) | ||
| I: 19.08.2021 21:00 | V: 26.08.2021 20:45 | Campeones: Olympiacos | ||||
| I | Rangers FC | - | FC Alashkert | 1:0 (0:0) | ||
| V | FC Alashkert | - | Rangers FC | 0:0 (0:0) | ||
| I: 19.08.2021 21:00 | V: 26.08.2021 17:00 | Campeones: Rangers FC | ||||
