30.04.2021 17:00 Berekum Chelsea - WAFA 2:3 (2:2)
01.05.2021 17:00 Eleven Wonders - Aduana Stars 2:1 (1:1)
20:00 Legon Cities - Asante Kotoko 0:1 (0:1)
02.05.2021 17:00 Bechem United - Inter Allies 2:1 (2:0)
17:00 Dreams FC - Hearts of Oak 2:0 (0:0)
17:00 Elmina Sharks - Ashanti Gold 2:1 (0:0)
17:00 Great Olympics - Liberty Professionals 2:0 (1:0)
17:00 King Faisal - Karela FC 1:1 (1:0)
17:00 Medeama SC - Ebusua Dwarfs 3:0 (0:0)
# Equipo P V E D Goles DG Pun.
1 Medeama SC, Ghana Medeama SC 22 11 6 5 29:19 10 39
2 Asante Kotoko, Ghana Asante Kotoko 22 10 8 4 22:10 12 38
3 Great Olympics, Ghana Great Olympics 22 11 4 7 24:19 5 37
4 Hearts of Oak, Ghana Hearts of Oak 22 9 7 6 29:18 11 34
5 Dreams FC, Ghana Dreams FC 22 9 7 6 31:21 10 34
6 Karela FC, Ghana Karela FC 22 9 7 6 28:23 5 34
7 Bechem United, Ghana Bechem United 22 9 6 7 27:31 -4 33
8 WAFA, Ghana WAFA 22 9 5 8 28:26 2 32
9 Ashanti Gold, Ghana Ashanti Gold 22 7 9 6 34:27 7 30
10 Aduana Stars, Ghana Aduana Stars 22 8 6 8 25:31 -6 30
11 Elmina Sharks, Ghana Elmina Sharks 22 7 8 7 23:29 -6 29
12 Ebusua Dwarfs, Ghana Ebusua Dwarfs 22 7 6 9 26:29 -3 27
13 Berekum Chelsea, Ghana Berekum Chelsea 22 7 6 9 23:28 -5 27
14 Eleven Wonders, Ghana Eleven Wonders 22 6 7 9 17:23 -6 25
15 Liberty Professionals, Ghana Liberty Professionals 22 6 6 10 18:27 -9 24
16 Legon Cities, Ghana Legon Cities 22 5 8 9 20:22 -2 23
17 King Faisal, Ghana King Faisal 22 5 8 9 21:31 -10 23
18 Inter Allies, Ghana Inter Allies 22 4 4 14 13:24 -11 16
  Champions League
  Descenso