28.01.2022 16:00 Asante Kotoko - Great Olympics 2:0 (2:0)
29.01.2022 16:00 Aduana Stars - Bechem United 0:1 (0:1)
30.01.2022 16:00 Ashanti Gold - Dreams FC 2:1 (1:0)
16:00 Berekum Chelsea - Accra Lions 3:1 (2:1)
16:00 Hearts of Oak - King Faisal 1:0 (1:0)
16:00 Legon Cities - Eleven Wonders 3:0 (0:0)
16:00 Medeama SC - Elmina Sharks 1:0 (0:0)
16:00 Real Tamale United - Karela FC 1:1 (1:0)
16:00 WAFA - Bibiani Gold Stars 1:0 (1:0)
# Equipo P V E D Goles DG Pun.
1 Asante Kotoko, Ghana Asante Kotoko 15 10 4 1 22:7 15 34
2 Bechem United, Ghana Bechem United 15 7 5 3 16:7 9 26
3 Medeama SC, Ghana Medeama SC 15 7 5 3 10:8 2 26
4 Hearts of Oak, Ghana Hearts of Oak 15 6 6 3 15:9 6 24
5 Aduana Stars, Ghana Aduana Stars 15 7 3 5 20:16 4 24
6 King Faisal, Ghana King Faisal 15 7 2 6 16:15 1 23
7 Great Olympics, Ghana Great Olympics 15 5 7 3 15:11 4 22
8 Karela FC, Ghana Karela FC 15 5 6 4 20:18 2 21
9 Ashanti Gold, Ghana Ashanti Gold 15 6 3 6 13:12 1 21
10 Dreams FC, Ghana Dreams FC 15 5 5 5 28:26 2 20
11 Real Tamale United, Ghana Real Tamale United 15 5 4 6 19:19 0 19
12 Berekum Chelsea, Ghana Berekum Chelsea 15 4 6 5 11:11 0 18
13 Legon Cities, Ghana Legon Cities 15 4 5 6 13:12 1 17
14 WAFA, Ghana WAFA 15 4 5 6 9:14 -5 17
15 Bibiani Gold Stars, Ghana Bibiani Gold Stars 15 5 1 9 14:19 -5 16
16 Accra Lions, Ghana Accra Lions 15 4 4 7 11:21 -10 16
17 Eleven Wonders, Ghana Eleven Wonders 15 4 3 8 12:21 -9 15
18 Elmina Sharks, Ghana Elmina Sharks 15 2 2 11 7:25 -18 8
  Champions League
  Descenso