 |
 |
|
|
| I | Niki Volou FC | - | Panetolikos | 0:1 (0:1) | ||
| V | Panetolikos | - | Niki Volou FC | 1:0 (0:0) | ||
| I: 01.12.2021 14:00 | V: 22.12.2021 16:00 | Campeones: Panetolikos | ||||
| I | Aris Saloniki | - | OFI Heraklion | 3:1 (2:0) | ||
| V | OFI Heraklion | - | Aris Saloniki | 0:2 (0:0) | ||
| I: 01.12.2021 16:00 | V: 23.12.2021 14:00 | Campeones: Aris Saloniki | ||||
| I | Levadiakos | - | Olympiacos | 3:2 (2:1) | ||
| V | Olympiacos | - | Levadiakos | 2:0 (2:0) | ||
| I: 01.12.2021 16:00 | V: 22.12.2021 18:00 | Campeones: Olympiacos | ||||
| I | Panathinaikos | - | Volos NFC | 2:1 (1:0) | ||
| V | Volos NFC | - | Panathinaikos | 0:0 (0:0) | ||
| I: 01.12.2021 18:00 | V: 23.12.2021 16:00 | Campeones: Panathinaikos | ||||
| I | AEK Athen | - | AE Kifisias | 4:0 (0:0) | ||
| V | AE Kifisias | - | AEK Athen | 1:1 (0:0) | ||
| I: 01.12.2021 19:15 | V: 23.12.2021 18:00 | Campeones: AEK Athen | ||||
| I | AE Lárissa | - | PAOK Saloniki | 1:1 (0:0) | ||
| V | PAOK Saloniki | - | AE Lárissa | 3:1 (1:0) | ||
| I: 01.12.2021 20:30 | V: 22.12.2021 16:00 | Campeones: PAOK Saloniki | ||||
| I | Agios Nikolaos | - | Anagennisi Karditsa | 0:1 (0:0) | ||
| V | Anagennisi Karditsa | - | Agios Nikolaos | 5:0 (1:0) | ||
| I: 02.12.2021 14:00 | V: 22.12.2021 14:00 | Campeones: Anagennisi Karditsa | ||||
| I | Lamia | - | Ionikos Nikea | 2:0 (1:0) | ||
| V | Ionikos Nikea | - | Lamia | 0:1 (0:1) | ||
| I: 02.12.2021 16:00 | V: 23.12.2021 16:00 | Campeones: Lamia | ||||
