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| 06.03.2022 | 18:00 | AEK Athen | - | Asteras Tripolis | 2:1 (1:0) | |
| 18:00 | Aris Saloniki | - | Olympiacos | 2:1 (0:1) | ||
| 18:00 | Atromitos | - | Panathinaikos | 0:2 (0:0) | ||
| 18:00 | Ionikos Nikea | - | Panetolikos | 1:2 (0:1) | ||
| 18:00 | Lamia | - | PAOK Saloniki | 0:2 (0:1) | ||
| 18:00 | OFI Heraklion | - | Apollon Smyrnis | 2:0 (0:0) | ||
| 18:00 | Volos NFC | - | PAS Giannina | 0:0 (0:0) |
| » Clasificación | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Olympiacos | 26 | 20 | 5 | 1 | 47:14 | 33 | 65 |
| 2 |
|
PAOK Saloniki | 26 | 16 | 5 | 5 | 50:24 | 26 | 53 |
| 3 |
|
AEK Athen | 26 | 14 | 4 | 8 | 42:28 | 14 | 46 |
| 4 |
|
Aris Saloniki | 26 | 13 | 6 | 7 | 28:21 | 7 | 45 |
| 5 |
|
Panathinaikos | 26 | 13 | 3 | 10 | 41:21 | 20 | 42 |
| 6 |
|
PAS Giannina | 26 | 11 | 7 | 8 | 28:24 | 4 | 40 |
| 7 |
|
OFI Heraklion | 26 | 9 | 10 | 7 | 33:32 | 1 | 37 |
| 8 |
|
Asteras Tripolis | 26 | 10 | 5 | 11 | 27:29 | -2 | 35 |
| 9 |
|
Panetolikos | 26 | 9 | 5 | 12 | 27:39 | -12 | 32 |
| 10 |
|
Volos NFC | 26 | 8 | 6 | 12 | 35:42 | -7 | 30 |
| 11 |
|
Ionikos Nikea | 26 | 6 | 8 | 12 | 26:34 | -8 | 26 |
| 12 |
|
Atromitos | 26 | 6 | 5 | 15 | 27:47 | -20 | 23 |
| 13 |
|
Lamia | 26 | 4 | 6 | 16 | 19:37 | -18 | 18 |
| 14 |
|
Apollon Smyrnis | 26 | 2 | 7 | 17 | 9:47 | -38 | 13 |
| Playoff | |
| Permanencia |
