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| 04.12.2010 | 16:15 | Iraklis Saloniki | - | Ergotelis | 1:1 (0:1) | |
| 16:15 | Panionios GSS | - | AO Kerkyra | 0:1 (0:1) | ||
| 18:30 | Panathinaikos | - | Panserraikos | 2:0 (1:0) | ||
| 05.12.2010 | 14:00 | Skoda Xanthi | - | Olympiacos Volou | 1:0 (0:0) | |
| 14:00 | Atromitos | - | AEK Athen | 1:1 (0:0) | ||
| 16:15 | Aris Saloniki | - | Asteras Tripolis | 1:0 (0:0) | ||
| 16:15 | AE Lárissa | - | PAOK Saloniki | 1:2 (1:1) | ||
| 18:30 | AO Kavala | - | Olympiacos | 0:1 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Olympiacos | 13 | 10 | 0 | 3 | 26:6 | 20 | 30 |
| 2 |
|
Panathinaikos | 13 | 9 | 3 | 1 | 23:10 | 13 | 30 |
| 3 |
|
AEK Athen | 13 | 6 | 2 | 5 | 19:14 | 5 | 20 |
| 4 |
|
PAOK Saloniki | 13 | 6 | 2 | 5 | 14:14 | 0 | 20 |
| 5 |
|
AO Kavala | 13 | 5 | 4 | 4 | 13:11 | 2 | 19 |
| 6 |
|
Aris Saloniki | 13 | 6 | 1 | 6 | 9:10 | -1 | 19 |
| 7 |
|
Skoda Xanthi | 13 | 4 | 5 | 4 | 12:15 | -3 | 17 |
| 8 |
|
Olympiacos Volou | 13 | 3 | 7 | 3 | 14:14 | 0 | 16 |
| 9 |
|
AO Kerkyra | 13 | 4 | 4 | 5 | 12:14 | -2 | 16 |
| 10 |
|
Iraklis Saloniki | 13 | 3 | 7 | 3 | 11:12 | -1 | 16 |
| 11 |
|
Atromitos | 13 | 3 | 6 | 4 | 12:15 | -3 | 15 |
| 12 |
|
Asteras Tripolis | 13 | 3 | 5 | 5 | 10:14 | -4 | 14 |
| 13 |
|
Panserraikos | 13 | 4 | 2 | 7 | 11:17 | -6 | 14 |
| 14 |
|
Ergotelis | 13 | 4 | 2 | 7 | 11:19 | -8 | 14 |
| 15 |
|
Panionios GSS | 13 | 4 | 1 | 8 | 8:17 | -9 | 13 |
| 16 |
|
AE Lárissa | 13 | 2 | 5 | 6 | 10:13 | -3 | 11 |
| Champions League | |
| Playoff | |
| Descenso |
