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| 04.12.2021 | 11:00 | Milan | - | SPAL 2013 Ferrara | 4:1 (2:1) | |
| 11:00 | Delfino Pescara | - | Juventus | 1:1 (0:0) | ||
| 13:00 | Nápoles | - | Inter | 0:2 (0:1) | ||
| 05.12.2021 | 10:45 | US Lecce | - | Fiorentina | 0:0 (0:0) | |
| 11:00 | Torino | - | Cagliari Calcio | 0:0 (0:0) | ||
| 13:00 | Empoli | - | Atalanta | 1:1 (0:1) | ||
| 14:30 | Roma | - | Sampdoria | 2:0 (1:0) | ||
| 17:00 | Sassuolo | - | Bolonia | 1:0 (0:0) | ||
| 06.12.2021 | 15:00 | Génova | - | Hellas Verona | 3:1 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Roma | 11 | 8 | 3 | 0 | 25:7 | 18 | 27 |
| 2 |
|
Nápoles | 11 | 6 | 1 | 4 | 13:17 | -4 | 19 |
| 3 |
|
Inter | 11 | 5 | 3 | 3 | 18:12 | 6 | 18 |
| 4 |
|
Fiorentina | 11 | 5 | 3 | 3 | 13:10 | 3 | 18 |
| 5 |
|
Torino | 11 | 5 | 3 | 3 | 18:16 | 2 | 18 |
| 6 |
|
Génova | 11 | 5 | 2 | 4 | 20:13 | 7 | 17 |
| 7 |
|
Empoli | 11 | 4 | 5 | 2 | 16:9 | 7 | 17 |
| 8 |
|
Juventus | 11 | 5 | 2 | 4 | 17:18 | -1 | 17 |
| 9 |
|
Sampdoria | 11 | 5 | 1 | 5 | 22:15 | 7 | 16 |
| 10 |
|
Sassuolo | 11 | 4 | 4 | 3 | 12:7 | 5 | 16 |
| 11 |
|
Cagliari Calcio | 11 | 4 | 4 | 3 | 14:14 | 0 | 16 |
| 12 |
|
Atalanta | 11 | 4 | 3 | 4 | 17:16 | 1 | 15 |
| 13 |
|
SPAL 2013 Ferrara | 11 | 4 | 2 | 5 | 12:23 | -11 | 14 |
| 14 |
|
Hellas Verona | 11 | 4 | 1 | 6 | 12:19 | -7 | 13 |
| 15 |
|
Milan | 11 | 3 | 2 | 6 | 15:19 | -4 | 11 |
| 16 |
|
US Lecce | 11 | 1 | 6 | 4 | 9:14 | -5 | 9 |
| 17 |
|
Bolonia | 11 | 2 | 1 | 8 | 13:22 | -9 | 7 |
| 18 |
|
Delfino Pescara | 11 | 1 | 2 | 8 | 8:23 | -15 | 5 |
| Playoff | |
| Próxima ronda | |
| Permanencia | |
| Descenso |
