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| 25.09.2021 | 11:00 | Atalanta | - | Milan | 2:0 (2:0) | |
| 13:00 | Inter | - | Juventus | 0:2 (0:2) | ||
| 15:00 | Torino | - | Empoli | 1:2 (1:1) | ||
| 26.09.2021 | 10:45 | Roma | - | Hellas Verona | 2:0 (0:0) | |
| 11:00 | SPAL 2013 Ferrara | - | Cagliari Calcio | 1:1 (0:0) | ||
| 13:00 | US Lecce | - | Génova | 0:1 (0:1) | ||
| 27.09.2021 | 15:00 | Fiorentina | - | Sassuolo | 1:0 (0:0) | |
| 15:00 | Sampdoria | - | Bolonia | 0:1 (0:0) | ||
| 17:00 | Nápoles | - | Delfino Pescara | 1:3 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Roma | 4 | 3 | 1 | 0 | 9:2 | 7 | 10 |
| 2 |
|
Génova | 4 | 3 | 0 | 1 | 8:1 | 7 | 9 |
| 3 |
|
Cagliari Calcio | 4 | 2 | 2 | 0 | 5:3 | 2 | 8 |
| 4 |
|
Empoli | 4 | 2 | 1 | 1 | 9:3 | 6 | 7 |
| 5 |
|
Atalanta | 4 | 2 | 1 | 1 | 10:7 | 3 | 7 |
| 6 |
|
Inter | 4 | 2 | 1 | 1 | 9:8 | 1 | 7 |
| 7 |
|
Juventus | 4 | 2 | 0 | 2 | 7:7 | 0 | 6 |
| 8 |
|
Torino | 4 | 2 | 0 | 2 | 6:9 | -3 | 6 |
| 9 |
|
Nápoles | 4 | 2 | 0 | 2 | 6:11 | -5 | 6 |
| 10 |
|
US Lecce | 4 | 1 | 2 | 1 | 4:3 | 1 | 5 |
| 11 |
|
SPAL 2013 Ferrara | 4 | 1 | 2 | 1 | 2:7 | -5 | 5 |
| 12 |
|
Sampdoria | 4 | 1 | 1 | 2 | 8:5 | 3 | 4 |
| 13 |
|
Fiorentina | 4 | 1 | 1 | 2 | 6:7 | -1 | 4 |
| 14 |
|
Bolonia | 4 | 1 | 1 | 2 | 4:6 | -2 | 4 |
| 15 |
|
Hellas Verona | 4 | 1 | 1 | 2 | 2:5 | -3 | 4 |
| 16 |
|
Delfino Pescara | 4 | 1 | 1 | 2 | 6:11 | -5 | 4 |
| 17 |
|
Milan | 4 | 0 | 2 | 2 | 3:6 | -3 | 2 |
| 18 |
|
Sassuolo | 4 | 0 | 1 | 3 | 1:4 | -3 | 1 |
| Playoff | |
| Próxima ronda | |
| Permanencia | |
| Descenso |
