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| 04.12.2021 | 15:00 | Milan | - | US Salernitana 1919 | 2:0 (2:0) | |
| 18:00 | Roma | - | Inter | 0:3 (0:3) | ||
| 20:45 | Nápoles | - | Atalanta | 2:3 (1:1) | ||
| 05.12.2021 | 12:30 | Bolonia | - | Fiorentina | 2:3 (1:1) | |
| 15:00 | Venezia FC | - | Hellas Verona | 3:4 (3:0) | ||
| 15:00 | Spezia Calcio | - | Sassuolo | 2:2 (1:0) | ||
| 18:00 | Sampdoria | - | Lazio | 1:3 (0:3) | ||
| 20:45 | Juventus | - | Génova | 2:0 (1:0) | ||
| 06.12.2021 | 18:30 | Empoli | - | Udinese | 3:1 (0:1) | |
| 20:45 | Cagliari Calcio | - | Torino | 1:1 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Milan | 16 | 12 | 2 | 2 | 35:18 | 17 | 38 |
| 2 |
|
Inter | 16 | 11 | 4 | 1 | 39:15 | 24 | 37 |
| 3 |
|
Nápoles | 16 | 11 | 3 | 2 | 34:12 | 22 | 36 |
| 4 |
|
Atalanta | 16 | 10 | 4 | 2 | 35:19 | 16 | 34 |
| 5 |
|
Juventus | 16 | 8 | 3 | 5 | 22:16 | 6 | 27 |
| 6 |
|
Fiorentina | 16 | 9 | 0 | 7 | 27:22 | 5 | 27 |
| 7 |
|
Roma | 16 | 8 | 1 | 7 | 24:19 | 5 | 25 |
| 8 |
|
Lazio | 16 | 7 | 4 | 5 | 32:30 | 2 | 25 |
| 9 |
|
Bolonia | 16 | 7 | 3 | 6 | 23:27 | -4 | 24 |
| 10 |
|
Hellas Verona | 16 | 6 | 5 | 5 | 32:28 | 4 | 23 |
| 11 |
|
Empoli | 16 | 7 | 2 | 7 | 26:29 | -3 | 23 |
| 12 |
|
Sassuolo | 16 | 5 | 5 | 6 | 26:25 | 1 | 20 |
| 13 |
|
Torino | 16 | 5 | 4 | 7 | 20:17 | 3 | 19 |
| 14 |
|
Udinese | 16 | 3 | 7 | 6 | 21:27 | -6 | 16 |
| 15 |
|
Sampdoria | 16 | 4 | 3 | 9 | 22:32 | -10 | 15 |
| 16 |
|
Venezia FC | 16 | 4 | 3 | 9 | 15:29 | -14 | 15 |
| 17 |
|
Spezia Calcio | 16 | 3 | 3 | 10 | 17:36 | -19 | 12 |
| 18 |
|
Cagliari Calcio | 16 | 1 | 7 | 8 | 17:30 | -13 | 10 |
| 19 |
|
Génova | 16 | 1 | 7 | 8 | 17:31 | -14 | 10 |
| 20 |
|
US Salernitana 1919 | 16 | 2 | 2 | 12 | 11:33 | -22 | 8 |
| Champions League | |
| Europa League | |
| ECL Ronda previa | |
| Descenso |
