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| 09.01.2022 | 12:30 | Venezia FC | - | Milan | 0:3 (0:1) | |
| 14:30 | Empoli | - | Sassuolo | 1:5 (1:2) | ||
| 16:30 | Nápoles | - | Sampdoria | 1:0 (1:0) | ||
| 16:30 | Udinese | - | Atalanta | 2:6 (0:3) | ||
| 18:30 | Roma | - | Juventus | 3:4 (1:1) | ||
| 18:30 | Génova | - | Spezia Calcio | 0:1 (0:1) | ||
| 20:45 | Hellas Verona | - | US Salernitana 1919 | 1:2 (0:1) | ||
| 20:45 | Inter | - | Lazio | 2:1 (1:1) | ||
| 10.01.2022 | 17:00 | Torino | - | Fiorentina | 4:0 (3:0) | |
| 11.01.2022 | 20:45 | Cagliari Calcio | - | Bolonia | 2:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Inter | 21 | 15 | 4 | 2 | 52:18 | 34 | 49 |
| 2 |
|
Milan | 21 | 15 | 3 | 3 | 46:23 | 23 | 48 |
| 3 |
|
Nápoles | 21 | 13 | 4 | 4 | 37:15 | 22 | 43 |
| 4 |
|
Atalanta | 21 | 12 | 6 | 3 | 48:30 | 18 | 42 |
| 5 |
|
Juventus | 21 | 11 | 5 | 5 | 32:21 | 11 | 38 |
| 6 |
|
Roma | 21 | 10 | 2 | 9 | 35:28 | 7 | 32 |
| 7 |
|
Lazio | 21 | 9 | 5 | 7 | 43:39 | 4 | 32 |
| 8 |
|
Fiorentina | 21 | 10 | 2 | 9 | 34:33 | 1 | 32 |
| 9 |
|
Bolonia | 21 | 9 | 3 | 9 | 30:34 | -4 | 30 |
| 10 |
|
Torino | 21 | 8 | 5 | 8 | 31:23 | 8 | 29 |
| 11 |
|
Sassuolo | 21 | 7 | 7 | 7 | 36:33 | 3 | 28 |
| 12 |
|
Empoli | 21 | 8 | 4 | 9 | 34:42 | -8 | 28 |
| 13 |
|
Hellas Verona | 21 | 7 | 6 | 8 | 37:35 | 2 | 27 |
| 14 |
|
Udinese | 21 | 5 | 8 | 8 | 32:35 | -3 | 23 |
| 15 |
|
Sampdoria | 21 | 5 | 5 | 11 | 28:38 | -10 | 20 |
| 16 |
|
Spezia Calcio | 21 | 5 | 4 | 12 | 21:41 | -20 | 19 |
| 17 |
|
Venezia FC | 21 | 4 | 5 | 12 | 19:39 | -20 | 17 |
| 18 |
|
US Salernitana 1919 | 21 | 5 | 2 | 14 | 16:44 | -28 | 17 |
| 19 |
|
Cagliari Calcio | 21 | 3 | 7 | 11 | 21:42 | -21 | 16 |
| 20 |
|
Génova | 21 | 1 | 9 | 11 | 20:39 | -19 | 12 |
| Champions League | |
| Europa League | |
| ECL Ronda previa | |
| Descenso |
