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| 02.02.2022 | 14:30 | Imolese Calcio | - | Viterbese | 0:3 (0:2) | |
| 14:30 | Olbia Calcio | - | Ancona 1905 | 1:2 (0:0) | ||
| 14:30 | Virtus Entella | - | Aquila Montevarchi | 5:1 (4:0) | ||
| 18:00 | ACN Siena 1904 | - | Teramo Calcio | 2:1 (1:1) | ||
| 18:00 | US Pontedera | - | Vis Pesaro | 1:1 (0:1) | ||
| 21:00 | Cesena FC | - | Lucchese | 1:1 (1:0) | ||
| 21:00 | Delfino Pescara | - | Carrarese Calcio | 1:1 (1:0) | ||
| 21:00 | Fermana FC | - | AS Gubbio | 1:1 (0:1) | ||
| 21:00 | AC Reggiana 1919 | - | Modena FC | 0:0 (0:0) | ||
| 21:00 | US Grosseto FC | - | US Pistoiese | 6:1 (2:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AC Reggiana 1919 | 21 | 14 | 7 | 0 | 40:11 | 29 | 49 |
| 2 |
|
Modena FC | 21 | 15 | 4 | 2 | 40:16 | 24 | 49 |
| 3 |
|
Cesena FC | 21 | 11 | 7 | 3 | 28:15 | 13 | 40 |
| 4 |
|
Virtus Entella | 21 | 10 | 6 | 5 | 37:23 | 14 | 36 |
| 5 |
|
Ancona 1905 | 21 | 10 | 5 | 6 | 37:26 | 11 | 35 |
| 6 |
|
Delfino Pescara | 21 | 8 | 9 | 4 | 29:24 | 5 | 33 |
| 7 |
|
AS Gubbio | 21 | 7 | 9 | 5 | 31:21 | 10 | 30 |
| 8 |
|
Vis Pesaro | 21 | 6 | 10 | 5 | 21:25 | -4 | 28 |
| 9 |
|
Lucchese | 21 | 6 | 9 | 6 | 20:22 | -2 | 27 |
| 10 |
|
Carrarese Calcio | 21 | 6 | 9 | 6 | 23:28 | -5 | 27 |
| 11 |
|
ACN Siena 1904 | 21 | 7 | 5 | 9 | 24:23 | 1 | 26 |
| 12 |
|
Olbia Calcio | 21 | 7 | 4 | 10 | 27:30 | -3 | 25 |
| 13 |
|
US Pontedera | 21 | 7 | 4 | 10 | 26:34 | -8 | 25 |
| 14 |
|
Fermana FC | 21 | 5 | 7 | 9 | 19:27 | -8 | 22 |
| 15 |
|
Aquila Montevarchi | 21 | 6 | 3 | 12 | 22:38 | -16 | 21 |
| 16 |
|
Teramo Calcio | 21 | 4 | 7 | 10 | 19:39 | -20 | 19 |
| 17 |
|
Imolese Calcio | 21 | 5 | 6 | 10 | 27:31 | -4 | 19 |
| 18 |
|
US Grosseto FC | 21 | 3 | 8 | 10 | 18:26 | -8 | 17 |
| 19 |
|
Viterbese | 21 | 3 | 8 | 10 | 24:33 | -9 | 17 |
| 20 |
|
US Pistoiese | 21 | 3 | 7 | 11 | 16:36 | -20 | 16 |
| Ascenso | |
| Playoff | |
| Permanencia | |
| Descenso |
