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| 16.04.2022 | 16:00 | Progrès Niedercorn | - | FC Rodange 91 | 1:2 (1:1) | |
| 18:00 | F91 Dudelange | - | CS FOLA Esch | 2:3 (0:2) | ||
| 18:00 | RM Hamm Benfica | - | Swift Hesperange | 0:4 (0:1) | ||
| 18:00 | US Hostert | - | FC Differdange 03 | 0:0 (0:0) | ||
| 18:00 | Jeunesse Esch | - | Victoria Rosport | 2:0 (1:0) | ||
| 18:00 | RFCU Luxemburg | - | Etzella Ettelbruck | 1:2 (1:0) | ||
| 18:00 | Union Titus Pétange | - | US Mondorf | 1:1 (0:0) | ||
| 18:00 | FC Wiltz 71 | - | UNA Strassen | 1:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
F91 Dudelange | 25 | 17 | 4 | 4 | 64:24 | 40 | 55 |
| 2 |
|
Swift Hesperange | 25 | 15 | 5 | 5 | 52:21 | 31 | 50 |
| 3 |
|
CS FOLA Esch | 25 | 14 | 7 | 4 | 56:34 | 22 | 49 |
| 4 |
|
Progrès Niedercorn | 25 | 14 | 6 | 5 | 59:30 | 29 | 48 |
| 5 |
|
FC Differdange 03 | 25 | 14 | 5 | 6 | 47:27 | 20 | 47 |
| 6 |
|
RFCU Luxemburg | 25 | 13 | 4 | 8 | 48:38 | 10 | 43 |
| 7 |
|
UNA Strassen | 25 | 11 | 8 | 6 | 41:26 | 15 | 41 |
| 8 |
|
Jeunesse Esch | 25 | 12 | 4 | 9 | 38:25 | 13 | 40 |
| 9 |
|
Etzella Ettelbruck | 25 | 11 | 0 | 14 | 40:60 | -20 | 33 |
| 10 |
|
Victoria Rosport | 25 | 8 | 7 | 10 | 40:48 | -8 | 31 |
| 11 |
|
Union Titus Pétange | 25 | 9 | 3 | 13 | 35:35 | 0 | 30 |
| 12 |
|
US Mondorf | 25 | 7 | 6 | 12 | 30:39 | -9 | 27 |
| 13 |
|
US Hostert | 25 | 7 | 5 | 13 | 34:49 | -15 | 26 |
| 14 |
|
FC Wiltz 71 | 25 | 7 | 4 | 14 | 31:45 | -14 | 25 |
| 15 |
|
FC Rodange 91 | 25 | 5 | 1 | 19 | 20:62 | -42 | 16 |
| 16 |
|
RM Hamm Benfica | 25 | 1 | 1 | 23 | 11:83 | -72 | 4 |
| CL Ronda previa | |
| ECL Ronda previa | |
| Permanencia | |
| Descenso |
