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| 10.09.2022 | 16:00 | UANL Tigres | - | Santos Laguna | 0:2 (0:1) | |
| 18:00 | Puebla FC | - | CF América | 1:4 (0:3) | ||
| 18:30 | Deportivo Toluca | - | Pumas UNAM | 1:0 (0:0) | ||
| 18:30 | Cruz Azul | - | FC Juárez | 5:0 (3:0) | ||
| 18:30 | Gallos Blancos | - | CF Pachuca | 2:4 (1:1) | ||
| 18:30 | Club León | - | Mazatlán FC | 1:0 (1:0) | ||
| 21:45 | Club Tijuana | - | CF Monterrey | 2:2 (2:0) | ||
| 11.09.2022 | 18:15 | Deportivo Guadalajara | - | Atlético San Luis | 3:1 (2:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 11 | 9 | 1 | 1 | 26:11 | 15 | 28 |
| 2 |
|
Club Necaxa | 10 | 6 | 1 | 3 | 18:5 | 13 | 19 |
| 3 |
|
Deportivo Toluca | 10 | 5 | 3 | 2 | 18:14 | 4 | 18 |
| 4 |
|
CF Pachuca | 11 | 4 | 5 | 2 | 17:11 | 6 | 17 |
| 5 |
|
CF América | 10 | 4 | 2 | 4 | 21:18 | 3 | 14 |
| 6 |
|
Cruz Azul | 11 | 4 | 2 | 5 | 22:23 | -1 | 14 |
| 7 |
|
Gallos Blancos | 11 | 3 | 3 | 5 | 16:17 | -1 | 12 |
| 8 |
|
Puebla FC | 11 | 2 | 1 | 8 | 13:24 | -11 | 7 |
| 9 |
|
FC Juárez | 11 | 2 | 0 | 9 | 13:41 | -28 | 6 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Tijuana | 11 | 8 | 2 | 1 | 33:11 | 22 | 26 |
| 2 |
|
CF Monterrey | 10 | 6 | 4 | 0 | 29:13 | 16 | 22 |
| 3 |
|
Deportivo Guadalajara | 11 | 6 | 1 | 4 | 23:15 | 8 | 19 |
| 4 |
|
Club León | 11 | 5 | 1 | 5 | 18:13 | 5 | 16 |
| 5 |
|
Atlas Guadalajara | 10 | 4 | 3 | 3 | 22:15 | 7 | 15 |
| 6 |
|
Santos Laguna | 11 | 4 | 3 | 4 | 25:19 | 6 | 15 |
| 7 |
|
UANL Tigres | 10 | 4 | 2 | 4 | 14:20 | -6 | 14 |
| 8 |
|
Atlético San Luis | 11 | 2 | 0 | 9 | 13:44 | -31 | 6 |
| 9 |
|
Mazatlán FC | 11 | 1 | 0 | 10 | 11:38 | -27 | 3 |
| Playoff | |
| Playoff |
