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| 23.01.2021 | 03:00 | Alacranes de Durango | - | Reboceros de La Piedad | 2:0 (2:0) | |
| 18:00 | Leones Negros II | - | Mineros de Fresnillo FC | 2:2 (1:0) | ||
| 22:00 | Tuzos de la UAZ | - | Gavilanes de Matamoros | 2:0 (2:0) | ||
| 23:00 | Saltillo FC | - | Mazorqueros | 3:2 (1:0) | ||
| 24.01.2021 | 00:00 | Colima FC | - | Tecos Fútbol Club | 1:2 (0:1) | |
| 25.01.2021 | 19:00 | Cimarrones de Sonora II | - | Atlético San Luis II | 0:2 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Alacranes de Durango | 13 | 9 | 2 | 2 | 26:10 | 16 | 32 |
| 2 |
|
Colima FC | 13 | 7 | 3 | 3 | 18:10 | 8 | 28 |
| 3 |
|
Reboceros de La Piedad | 13 | 7 | 2 | 4 | 27:17 | 10 | 27 |
| 4 |
|
Mineros de Fresnillo FC | 13 | 6 | 4 | 3 | 27:18 | 9 | 25 |
| 5 |
|
Gavilanes de Matamoros | 13 | 7 | 2 | 4 | 10:11 | -1 | 23 |
| 6 |
|
Atlético San Luis II | 13 | 5 | 2 | 6 | 12:14 | -2 | 19 |
| 7 |
|
Mazorqueros | 13 | 5 | 2 | 6 | 16:20 | -4 | 17 |
| 8 |
|
Saltillo FC | 13 | 3 | 6 | 4 | 14:22 | -8 | 17 |
| 9 |
|
Tuzos de la UAZ | 13 | 3 | 5 | 5 | 14:16 | -2 | 16 |
| 10 |
|
Tecos Fútbol Club | 13 | 3 | 3 | 7 | 11:17 | -6 | 13 |
| 11 |
|
Leones Negros II | 13 | 3 | 3 | 7 | 16:25 | -9 | 13 |
| 12 |
|
Cimarrones de Sonora II | 13 | 1 | 4 | 8 | 8:19 | -11 | 7 |
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