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| I | CF Pachuca | - | Cruz Azul | 0:0 (0:0) | ||
| V | Cruz Azul | - | CF Pachuca | 1:0 (0:0) | ||
| I: 20.05.2021 03:30 | V: 23.05.2021 03:00 | Campeones: Cruz Azul | ||||
| I | Santos Laguna | - | Puebla FC | 3:0 (2:0) | ||
| V | Puebla FC | - | Santos Laguna | 1:0 (0:0) | ||
| I: 21.05.2021 04:00 | V: 24.05.2021 02:00 | Campeones: Santos Laguna | ||||
