 |
 |
|
|
| 24.09.2021 | 04:00 | CF Pachuca | - | Club Necaxa | 1:0 (1:0) | |
| 25.09.2021 | 03:00 | Puebla FC | - | Cruz Azul | 1:1 (1:1) | |
| 04:06 | Club Tijuana | - | Mazatlán FC | 0:0 (0:0) | ||
| 26.09.2021 | 00:00 | Atlas Guadalajara | - | Club León | 2:0 (1:0) | |
| 02:00 | UANL Tigres | - | Pumas UNAM | 0:0 (0:0) | ||
| 04:00 | CF América | - | Deportivo Guadalajara | 0:0 (0:0) | ||
| 19:00 | Deportivo Toluca | - | Atlético San Luis | 1:2 (1:2) | ||
| 27.09.2021 | 02:06 | Santos Laguna | - | CF Monterrey | 1:2 (0:0) | |
| 09.10.2021 | 02:00 | FC Juárez | - | Gallos Blancos | 0:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 10 | 6 | 3 | 1 | 13:6 | 7 | 21 |
| 2 |
|
Deportivo Toluca | 10 | 6 | 2 | 2 | 18:13 | 5 | 20 |
| 3 |
|
Atlas Guadalajara | 10 | 5 | 4 | 1 | 12:4 | 8 | 19 |
| 4 |
|
CF Monterrey | 10 | 4 | 5 | 1 | 15:9 | 6 | 17 |
| 5 |
|
Atlético San Luis | 10 | 4 | 5 | 1 | 16:11 | 5 | 17 |
| 6 |
|
Club León | 10 | 4 | 3 | 3 | 13:12 | 1 | 15 |
| 7 |
|
Cruz Azul | 10 | 3 | 5 | 2 | 13:9 | 4 | 14 |
| 8 |
|
UANL Tigres | 10 | 3 | 5 | 2 | 14:11 | 3 | 14 |
| 9 |
|
Deportivo Guadalajara | 10 | 3 | 5 | 2 | 8:8 | 0 | 14 |
| 10 |
|
Santos Laguna | 10 | 2 | 6 | 2 | 12:9 | 3 | 12 |
| 11 |
|
CF Pachuca | 10 | 3 | 2 | 5 | 11:10 | 1 | 11 |
| 12 |
|
Mazatlán FC | 10 | 2 | 5 | 3 | 11:16 | -5 | 11 |
| 13 |
|
Puebla FC | 10 | 1 | 6 | 3 | 8:13 | -5 | 9 |
| 14 |
|
FC Juárez | 10 | 2 | 3 | 5 | 8:14 | -6 | 9 |
| 15 |
|
Club Necaxa | 10 | 3 | 0 | 7 | 9:16 | -7 | 9 |
| 16 |
|
Pumas UNAM | 10 | 1 | 5 | 4 | 6:12 | -6 | 8 |
| 17 |
|
Gallos Blancos | 10 | 1 | 4 | 5 | 4:10 | -6 | 7 |
| 18 |
|
Club Tijuana | 10 | 1 | 4 | 5 | 9:17 | -8 | 7 |
| Playoff | |
| Playoff |
