 |
 |
|
|
| 15.10.2021 | 03:00 | Gallos Blancos | - | Club Tijuana | 1:1 (0:1) | |
| 16.10.2021 | 02:00 | Club Necaxa | - | Puebla FC | 0:1 (0:0) | |
| 04:00 | Mazatlán FC | - | Atlas Guadalajara | 1:0 (1:0) | ||
| 17.10.2021 | 00:00 | CF Monterrey | - | Club León | 0:1 (0:1) | |
| 02:00 | Atlético San Luis | - | CF América | 0:1 (0:0) | ||
| 02:00 | CF Pachuca | - | Santos Laguna | 1:1 (0:0) | ||
| 04:00 | Cruz Azul | - | UANL Tigres | 1:1 (1:1) | ||
| 19:00 | Pumas UNAM | - | FC Juárez | 1:0 (0:0) | ||
| 18.10.2021 | 00:00 | Deportivo Guadalajara | - | Deportivo Toluca | 2:0 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 13 | 8 | 4 | 1 | 17:7 | 10 | 28 |
| 2 |
|
Atlas Guadalajara | 13 | 6 | 4 | 3 | 13:6 | 7 | 22 |
| 3 |
|
Club León | 13 | 6 | 4 | 3 | 15:12 | 3 | 22 |
| 4 |
|
Deportivo Toluca | 13 | 6 | 3 | 4 | 19:18 | 1 | 21 |
| 5 |
|
CF Monterrey | 13 | 5 | 5 | 3 | 18:13 | 5 | 20 |
| 6 |
|
Santos Laguna | 13 | 4 | 7 | 2 | 17:10 | 7 | 19 |
| 7 |
|
UANL Tigres | 13 | 4 | 7 | 2 | 18:12 | 6 | 19 |
| 8 |
|
Cruz Azul | 13 | 4 | 6 | 3 | 15:11 | 4 | 18 |
| 9 |
|
Atlético San Luis | 13 | 4 | 6 | 3 | 16:15 | 1 | 18 |
| 10 |
|
Deportivo Guadalajara | 13 | 4 | 5 | 4 | 10:10 | 0 | 17 |
| 11 |
|
Mazatlán FC | 13 | 4 | 5 | 4 | 15:18 | -3 | 17 |
| 12 |
|
CF Pachuca | 13 | 4 | 4 | 5 | 15:13 | 2 | 16 |
| 13 |
|
Puebla FC | 13 | 3 | 6 | 4 | 11:15 | -4 | 15 |
| 14 |
|
Club Necaxa | 13 | 4 | 1 | 8 | 12:17 | -5 | 13 |
| 15 |
|
Gallos Blancos | 13 | 2 | 6 | 5 | 7:12 | -5 | 12 |
| 16 |
|
FC Juárez | 13 | 3 | 3 | 7 | 12:19 | -7 | 12 |
| 17 |
|
Pumas UNAM | 13 | 2 | 5 | 6 | 7:17 | -10 | 11 |
| 18 |
|
Club Tijuana | 13 | 1 | 5 | 7 | 10:22 | -12 | 8 |
| Playoff | |
| Playoff |
