 |
 |
|
|
| 28.08.2021 | 02:00 | Mazatlán FC | - | Atlético San Luis | 2:2 (1:1) | |
| 04:00 | Puebla FC | - | Gallos Blancos | 1:0 (0:0) | ||
| 04:05 | Club Tijuana | - | CF Monterrey | 2:2 (1:2) | ||
| 29.08.2021 | 00:00 | Deportivo Guadalajara | - | Club Necaxa | 2:1 (1:0) | |
| 02:00 | UANL Tigres | - | Atlas Guadalajara | 1:1 (1:0) | ||
| 04:00 | Club León | - | CF América | 1:1 (1:1) | ||
| 19:00 | Deportivo Toluca | - | Pumas UNAM | 2:1 (1:1) | ||
| 30.08.2021 | 01:00 | Santos Laguna | - | FC Juárez | 2:0 (0:0) | |
| 03:00 | Cruz Azul | - | CF Pachuca | 1:1 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 7 | 5 | 2 | 0 | 10:3 | 7 | 17 |
| 2 |
|
Club León | 7 | 4 | 2 | 1 | 11:7 | 4 | 14 |
| 3 |
|
Deportivo Toluca | 7 | 4 | 2 | 1 | 12:9 | 3 | 14 |
| 4 |
|
UANL Tigres | 7 | 3 | 3 | 1 | 12:7 | 5 | 12 |
| 5 |
|
Santos Laguna | 7 | 2 | 5 | 0 | 9:4 | 5 | 11 |
| 6 |
|
CF Monterrey | 7 | 2 | 5 | 0 | 10:6 | 4 | 11 |
| 7 |
|
Cruz Azul | 7 | 2 | 4 | 1 | 9:6 | 3 | 10 |
| 8 |
|
Atlas Guadalajara | 7 | 2 | 4 | 1 | 5:3 | 2 | 10 |
| 9 |
|
Atlético San Luis | 7 | 2 | 4 | 1 | 8:7 | 1 | 10 |
| 10 |
|
Club Necaxa | 7 | 3 | 0 | 4 | 9:9 | 0 | 9 |
| 11 |
|
Deportivo Guadalajara | 7 | 2 | 3 | 2 | 7:8 | -1 | 9 |
| 12 |
|
Mazatlán FC | 7 | 2 | 3 | 2 | 9:12 | -3 | 9 |
| 13 |
|
CF Pachuca | 7 | 2 | 2 | 3 | 9:7 | 2 | 8 |
| 14 |
|
Puebla FC | 7 | 1 | 3 | 3 | 4:9 | -5 | 6 |
| 15 |
|
Pumas UNAM | 7 | 1 | 2 | 4 | 4:10 | -6 | 5 |
| 16 |
|
Club Tijuana | 7 | 0 | 3 | 4 | 6:12 | -6 | 3 |
| 17 |
|
Gallos Blancos | 7 | 0 | 3 | 4 | 1:8 | -7 | 3 |
| 18 |
|
FC Juárez | 7 | 0 | 2 | 5 | 5:13 | -8 | 2 |
| Playoff | |
| Playoff |
