 |
 |
|
|
| 17.09.2021 | 02:00 | Atlético San Luis | - | Club Tijuana | 4:1 (3:1) | |
| 18.09.2021 | 04:00 | Club Necaxa | - | Atlas Guadalajara | 0:3 (0:2) | |
| 19.09.2021 | 00:00 | Club León | - | FC Juárez | 0:1 (0:0) | |
| 02:00 | Deportivo Toluca | - | CF América | 3:1 (2:1) | ||
| 04:00 | Mazatlán FC | - | Pumas UNAM | 2:2 (1:0) | ||
| 04:00 | Deportivo Guadalajara | - | CF Pachuca | 1:0 (0:0) | ||
| 20.09.2021 | 02:00 | Cruz Azul | - | Gallos Blancos | 2:0 (1:0) | |
| 02:06 | CF Monterrey | - | UANL Tigres | 2:0 (1:0) | ||
| 04:06 | Santos Laguna | - | Puebla FC | 1:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 9 | 6 | 2 | 1 | 13:6 | 7 | 20 |
| 2 |
|
Deportivo Toluca | 9 | 6 | 2 | 1 | 17:11 | 6 | 20 |
| 3 |
|
Atlas Guadalajara | 9 | 4 | 4 | 1 | 10:4 | 6 | 16 |
| 4 |
|
Club León | 9 | 4 | 3 | 2 | 13:10 | 3 | 15 |
| 5 |
|
CF Monterrey | 9 | 3 | 5 | 1 | 13:8 | 5 | 14 |
| 6 |
|
Atlético San Luis | 9 | 3 | 5 | 1 | 14:10 | 4 | 14 |
| 7 |
|
Cruz Azul | 9 | 3 | 4 | 2 | 12:8 | 4 | 13 |
| 8 |
|
UANL Tigres | 9 | 3 | 4 | 2 | 14:11 | 3 | 13 |
| 9 |
|
Deportivo Guadalajara | 9 | 3 | 4 | 2 | 8:8 | 0 | 13 |
| 10 |
|
Santos Laguna | 9 | 2 | 6 | 1 | 11:7 | 4 | 12 |
| 11 |
|
Mazatlán FC | 9 | 2 | 4 | 3 | 11:16 | -5 | 10 |
| 12 |
|
Club Necaxa | 9 | 3 | 0 | 6 | 9:15 | -6 | 9 |
| 13 |
|
CF Pachuca | 9 | 2 | 2 | 5 | 10:10 | 0 | 8 |
| 14 |
|
Puebla FC | 9 | 1 | 5 | 3 | 7:12 | -5 | 8 |
| 15 |
|
FC Juárez | 9 | 2 | 2 | 5 | 8:14 | -6 | 8 |
| 16 |
|
Pumas UNAM | 9 | 1 | 4 | 4 | 6:12 | -6 | 7 |
| 17 |
|
Gallos Blancos | 9 | 1 | 3 | 5 | 4:10 | -6 | 6 |
| 18 |
|
Club Tijuana | 9 | 1 | 3 | 5 | 9:17 | -8 | 6 |
| Playoff | |
| Playoff |
