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| 23.03.2022 | 15:00 | Cruz Azul | - | Pumas UNAM | 0:2 (0:1) | |
| 30.03.2022 | 18:00 | Deportivo Guadalajara | - | CF Monterrey | 5:1 (3:1) | |
| 16.04.2022 | 16:00 | Atlético San Luis | - | Club León | 1:3 (1:1) | |
| 16:00 | Atlas Guadalajara | - | Mazatlán FC | 5:0 (2:0) | ||
| 16:00 | Gallos Blancos | - | Club Necaxa | 0:2 (0:1) | ||
| 16:00 | Deportivo Toluca | - | CF América | 1:2 (0:1) | ||
| 17:00 | FC Juárez | - | Puebla FC | 0:1 (0:1) | ||
| 20.04.2022 | 19:00 | Club Tijuana | - | Santos Laguna | 0:1 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 13 | 8 | 2 | 3 | 20:8 | 12 | 26 |
| 2 |
|
Club Necaxa | 13 | 7 | 4 | 2 | 21:19 | 2 | 25 |
| 3 |
|
Deportivo Toluca | 14 | 7 | 2 | 5 | 33:19 | 14 | 23 |
| 4 |
|
Cruz Azul | 14 | 7 | 2 | 5 | 29:20 | 9 | 23 |
| 5 |
|
CF América | 13 | 7 | 1 | 5 | 18:15 | 3 | 22 |
| 6 |
|
Puebla FC | 13 | 5 | 2 | 6 | 21:19 | 2 | 17 |
| 7 |
|
CF Pachuca | 13 | 4 | 5 | 4 | 25:24 | 1 | 17 |
| 8 |
|
Gallos Blancos | 14 | 2 | 3 | 9 | 9:28 | -19 | 9 |
| 9 |
|
FC Juárez | 13 | 2 | 1 | 10 | 15:39 | -24 | 7 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 13 | 10 | 2 | 1 | 33:11 | 22 | 32 |
| 2 |
|
Atlas Guadalajara | 13 | 8 | 3 | 2 | 31:15 | 16 | 27 |
| 3 |
|
Santos Laguna | 13 | 7 | 2 | 4 | 20:14 | 6 | 23 |
| 4 |
|
UANL Tigres | 13 | 6 | 4 | 3 | 18:16 | 2 | 22 |
| 5 |
|
Club León | 13 | 5 | 2 | 6 | 17:21 | -4 | 17 |
| 6 |
|
CF Monterrey | 14 | 3 | 6 | 5 | 21:23 | -2 | 15 |
| 7 |
|
Club Tijuana | 13 | 4 | 1 | 8 | 11:21 | -10 | 13 |
| 8 |
|
Atlético San Luis | 14 | 2 | 3 | 9 | 14:25 | -11 | 9 |
| 9 |
|
Mazatlán FC | 14 | 2 | 3 | 9 | 16:35 | -19 | 9 |
| Playoff | |
| Playoff |
