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| I | Pumas UNAM | - | Club Necaxa | 2:1 (1:1) | ||
| V | Club Necaxa | - | Pumas UNAM | 3:1 (1:1) | ||
| I: 25.11.2020 19:00 | V: 28.11.2020 17:00 | Campeones: Club Necaxa | ||||
| I | Club Tijuana | - | Atlas Guadalajara | 1:1 (1:0) | ||
| V | Atlas Guadalajara | - | Club Tijuana | 4:0 (3:0) | ||
| I: 26.11.2020 04:00 | V: 28.11.2020 16:00 | Campeones: Atlas Guadalajara | ||||
| I | Deportivo Toluca | - | Deportivo Guadalajara | 3:1 (2:1) | ||
| V | Deportivo Guadalajara | - | Deportivo Toluca | 3:2 (1:1) | ||
| I: 26.11.2020 18:30 | V: 29.11.2020 18:15 | Campeones: Deportivo Toluca | ||||
| I | Puebla FC | - | CF Pachuca | 0:3 (0:1) | ||
| V | CF Pachuca | - | Puebla FC | 2:5 (1:3) | ||
| I: 26.11.2020 18:45 | V: 29.11.2020 17:00 | Campeones: Puebla FC | ||||
