 |
 |
|
| 29.04.2021 | 19:00 | Atlético San Luis | - | CF Pachuca | 1:2 (1:1) | |
| 30.04.2021 | 18:15 | Club Necaxa | - | Atlas Guadalajara | 1:0 (0:0) | |
| 19:30 | FC Juárez | - | Deportivo Toluca | 1:2 (0:0) | ||
| 01.05.2021 | 16:00 | Pumas UNAM | - | CF América | 8:2 (3:1) | |
| 18:15 | Deportivo Guadalajara | - | UANL Tigres | 1:0 (0:0) | ||
| 18:15 | Cruz Azul | - | Club Tijuana | 1:0 (0:0) | ||
| 18:30 | CF Monterrey | - | Mazatlán FC | 7:2 (1:1) | ||
| 18:30 | Club León | - | Gallos Blancos | 2:0 (1:0) | ||
| 02.05.2021 | 16:00 | Santos Laguna | - | Puebla FC | 1:0 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 17 | 12 | 3 | 2 | 50:25 | 25 | 52 |
| 2 |
|
Atlas Guadalajara | 17 | 10 | 2 | 5 | 27:19 | 8 | 44 |
| 3 |
|
Club León | 17 | 10 | 5 | 2 | 32:17 | 15 | 42 |
| 4 |
|
Pumas UNAM | 17 | 9 | 2 | 6 | 40:22 | 18 | 37 |
| 5 |
|
Santos Laguna | 17 | 8 | 4 | 5 | 30:26 | 4 | 37 |
| 6 |
|
Deportivo Guadalajara | 17 | 8 | 5 | 4 | 28:18 | 10 | 36 |
| 7 |
|
Cruz Azul | 17 | 9 | 1 | 7 | 30:24 | 6 | 36 |
| 8 |
|
Deportivo Toluca | 17 | 7 | 6 | 4 | 27:21 | 6 | 35 |
| 9 |
|
UANL Tigres | 17 | 8 | 4 | 5 | 26:22 | 4 | 35 |
| 10 |
|
Club Necaxa | 17 | 7 | 3 | 7 | 27:21 | 6 | 34 |
| 11 |
|
Club Tijuana | 17 | 7 | 3 | 7 | 24:23 | 1 | 33 |
| 12 |
|
CF Monterrey | 17 | 7 | 2 | 8 | 31:27 | 4 | 30 |
| 13 |
|
FC Juárez | 17 | 6 | 2 | 9 | 20:23 | -3 | 27 |
| 14 |
|
Mazatlán FC | 17 | 4 | 5 | 8 | 19:35 | -16 | 27 |
| 15 |
|
Puebla FC | 17 | 5 | 3 | 9 | 25:35 | -10 | 25 |
| 16 |
|
Atlético San Luis | 17 | 2 | 2 | 13 | 14:47 | -33 | 20 |
| 17 |
|
Gallos Blancos | 17 | 3 | 3 | 11 | 17:35 | -18 | 18 |
| 18 |
|
CF América | 17 | 3 | 1 | 13 | 20:47 | -27 | 16 |
| Playoff |
